Results 91 to 100 of about 2,221,895 (307)

Association between genetically proxied PPARG activation and early onset Alzheimer's disease: A drug target Mendelian randomization study

Journal of Alzheimer's Disease Reports
Background:  Early-onset Alzheimer's disease (EOAD), which has an onset before the age of 65, is overshadowed by the more prevalent late-onset Alzheimer's disease (LOAD).
Lingyu Zhang, Yi Wu, Qianqian Jin, Chunfang Wang   +3 more
doaj   +1 more source

Experimental Sinusitis in a Rhinogenic Model

The Laryngoscope, 2004
AbstractObjectives/Hypothesis: The objectives were to determine the optimal sinusitis induction period and to examine microbiological and histopathological changes of sinusitis recovery stage in a rhinogenic sinusitis model.Methods: A synthetic sponge was inserted into the right‐side nasal cavities of rabbits.
Kara, Cüneyt Orhan, Çetin, Çiğdem Banu, Demirkan, Neşe, Şengül, Mustafa, Topuz, Bülent, Şafak Pinar, H., Pakdemirli, E.   +6 more
openaire   +6 more sources

Experimental models of dermatological diseases

, 2019
This review presents analysis of experimental models of atopic dermatitis, psoriasis, skin symptoms of autoimmune systemic connective tissue diseases, and blistering skin diseases.
Yu. F. Fefelova, M. B. Aksenenko, E. Yu. Sergeeva, O. N. Sergeeva, T. G. Ruksha   +4 more
core   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Epithelial Ovarian Cancer Experimental Models

, 2014
Epithelial ovarian cancer (OvCa) is associated with high mortality and, as the majority (>75%) of women with OvCa have metastatic disease at the time of diagnosis, rates of survival have not changed appreciably over 30 years.
Pilrose, J, Matei, D, Haluska, P., Burdette, JE, Hales, DB, Lengyel, E, Nephew, KP, Stack, MS, Kenny, HA   +8 more
core   +3 more sources

Experimental models of hepatocellular carcinoma

, 2008
Hepatocellular carcinoma (HCC) is a common and deadly cancer whose pathogenesis is incompletely understood. Comparative genomic studies from human HCC samples have classified HCCs into different molecular subgroups; yet, the unifying feature of this ...
Newell, Philippa, Koike, Kazuhiko, Friedman, Scott L., Villanueva, Augusto, Llovet, Josep M.   +4 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

COVID-AMD database for coronavirus-infected animal models with comparative analysis tools

Scientific Reports
Respiratory infections caused by coronaviruses have posed serious and unpredictably public health threats; reliable animal models continue to be essential for advancing our understanding of the virus’s transmission, pathophysiology, and immunological ...
Yue Wu, Lu Li, Kai Wang, Yang Zhang, Jue Wang, Ting-Ting Feng, Yi-Tong Li, Qi Kong   +7 more
doaj   +1 more source