Results 61 to 70 of about 1,454,596 (276)

Motion as manipulation: Implementation of motion and force analogies by event-file binding and action planning\ud [PDF]

, 2011
Tool improvisation analogies are a special case of motion and force analogies that appear to be implemented pre-conceptually, in many species, by event-file binding and action planning.
Fields, Chris
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

A Parametric Hierarchical Planner for Experimenting Abstraction Techniques [PDF]

, 2003
This paper presents a parametric system, devised and implemented to perform hierarchical planning by delegating the actual search to an external planner (the "parameter") at any level of abstraction, including the ground one.
ARMANO, GIULIANO, CHERCHI G, VARGIU, ELOISA   +2 more
core  

Probabilistic Hybrid Action Models for Predicting Concurrent Percept-driven Robot Behavior

, 2005
This article develops Probabilistic Hybrid Action Models (PHAMs), a realistic causal model for predicting the behavior generated by modern percept-driven robot plans.
Beetz, M., Grosskreutz, H.
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Experimental Planning for Production of β-D-Glucan: Purification and Fluorescence Properties from Basidiomycete Strains

Separations
Fruit and coffee industries are responsible for huge quantities of agro-industrial wastes which is of great environmental and public health concern. Therefore, the aim of this work involves the use of such wastes for the production of β-D-glucan from ...
Luís Marques, Amin Karmali
doaj   +1 more source

Conceptualizing Testbed Planning: Urban Planning in the Intersection between Experimental and Public Sector Logics

Urban Planning, 2020
Urban planning is, in many countries, increasingly becoming intertwined with local climate ambitions, investments in urban attractiveness and “smart city” innovation measures.
Lina Berglund-Snodgrass, Dalia Mukhtar-Landgren   +1 more
doaj   +1 more source

Genetic Aberrations and Interaction of NEK2 and TP53 Accelerate Aggressiveness of Multiple Myeloma

Advanced Science, 2022
It has been previously shown that (never in mitosis gene A)‐related kinase 2 (NEK2) is upregulated in multiple myeloma (MM) and contributes to drug resistance. However, the mechanisms behind this upregulation remain poorly understood.
Xiangling Feng, Jiaojiao Guo, Gang An, Yangbowen Wu, Zhenhao Liu, Bin Meng, Nihan He, Xinying Zhao, Shilian Chen, Yinghong Zhu, Jiliang Xia, Xin Li, Zhiyong Yu, Ruixuan Li, Guofeng Ren, Jihua Chen, Minghua Wu, Yanjuan He, Lugui Qiu, Jiaxi Zhou, Wen Zhou   +20 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

SPREAD: a high-resolution daily gridded precipitation dataset for Spain – an extreme events frequency and intensity overview [PDF]

Earth System Science Data, 2017
A high-resolution daily gridded precipitation dataset was built from raw data of 12 858 observatories covering a period from 1950 to 2012 in peninsular Spain and 1971 to 2012 in Balearic and Canary islands.
R. Serrano-Notivoli, R. Serrano-Notivoli, R. Serrano-Notivoli, S. Beguería, M. Á. Saz, M. Á. Saz, L. A. Longares, L. A. Longares, M. de Luis, M. de Luis   +9 more
doaj   +1 more source