Results 31 to 40 of about 513,957 (266)

Population model‐based analysis of the memory B‐cell response following belimumab therapy in the treatment of systemic lupus erythematosus

CPT: Pharmacometrics & Systems Pharmacology, 2023
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by B‐cell hyperactivity and breach of tolerance. Autoreactive memory B cells, which have a decreased activation threshold and the ability to survive in absence of antigen, are ...
Richard Dimelow, William R. Gillespie, Andre vanMaurik   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Effect analysis of a virtual simulation experimental platform in teaching pulpotomy

BMC Medical Education, 2022
Background The experimental teaching of pediatric dentistry is a bridge between theoretical study and clinical practice, and virtual simulation technology provides a new method of instruction.
Jiaxuan Lu, Xin Yang, Wei Zhao, Jiacheng Lin   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Straw resource performance and application potential assessment

Shenzhen Daxue xuebao. Ligong ban
Renewable straw resources have not been widely applied due to the lack of performance assessment. This study selected six representative characteristics of rural farmhouses for field research to understand the current state of rural housing and explore ...
CUI Dongjin, SU Chang, ZHU Mengye, ZHAO Haitian   +3 more
doaj   +1 more source

Optimal plot size for experimentation of common beans (Phaseolus vulgaris L.) in the northern region of Minas Gerais, Brazil

Revista de la Facultad de Ciencias Agrarias, 2021
The objective was to evaluate the minimum size of experimental plots for the common bean (Phaseolus vulgaris L.) using the modified maximum curvature method. The experiment consisted of a uniformity trial with the cultivar BRSFC-402 sown at a spacing
Bruno Vinícius Castro Guimarães, Abner José de Carvalho, Ignacio Aspiazú, Liliane Santana da Silva, Rafael Rogério Pereira da Silva, Amanda Maria Leal Pimenta, Marielly Maria Almeida Moura   +6 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Experimental repetitive quantum channel simulation [PDF]

Science Bulletin, 2018
Universal control of quantum systems is a major goal to be achieved for quantum information processing, which demands thorough understanding of fundamental quantum mechanics and promises applications of quantum technologies. So far, most studies concentrate on ideally isolated quantum systems governed by unitary evolutions, while practical quantum ...
Hu, Ling, Mu, Xianghao, Cai, Weizhou, Ma, Yuwei, Xu, Yuan, Wang, Haiyan, Song, YiPu, Zou, Chang-Ling, Sun, Luyan   +8 more
openaire   +3 more sources