Results 51 to 60 of about 513,957 (266)

Secure and Efficient Large Content Broadcasting in Mobile Social Networks

IEEE Access, 2018
Most of existing mobile social systems are built on the presence of communication infrastructures and thereby rely on the reliability of the underlying communication infrastructures. As a consequence, if the infrastructures are inaccessible to users, the
Tingting Fu, Peng Liu, Yue Ding, Yuan Zhang   +3 more
doaj   +1 more source

A LOGICAL AND ONTOLOGICAL FRAMEWORK FOR KNOWLEDGE DISCOVERY ON GENE REGULATORY NETWORKS. CASE STUDY: BILE ACID AND XENOBIOTIC SYSTEM (BAXS)

Journal of Bioinformatics and Genomics, 2020
This work aims to develop a novel computational framework for automatic or semi-automatic modeling of gene regulatory networks, in which possible connections between genetic structural knowledge and other forms of knowledge available about GRNs can be ...
López, J., Ramírez, Y., Dávila, J., Bastidas, M.   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Improvement of the Decision Support System Model for College Students' Entrepreneurship Path Planning Based on Tree Pruning Algorithm

Engineering Reports
Aiming at the problems of high decision‐making difficulty and insufficient adaptability of traditional algorithms in college students' entrepreneurship path planning, this paper proposes a decision support system model for college students ...
Lu Gao, Renjia Zhang
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Recursive simulation and experimental frame for multiscale simulation [PDF]

, 2009
In this paper, we present a formal and operational framework for multiscale modeling and simulation. We focus on scale transfer viewed as the coupling between two models of the same system, one at the microscopic scale and the other at the macroscopic scale.
Bonte, Bruno, Duboz, Raphaël, Quesnel, Gauthier, Müller, Jean Pierre   +3 more
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Experimental Quantum Simulation of Chemical Dynamics

Journal of the American Chemical Society
8 pages, 3 ...
Tomas Navickas, Ryan J. MacDonell, Christophe H. Valahu, Vanessa C. Olaya-Agudelo, Frank Scuccimarra, Maverick J. Millican, Vassili G. Matsos, Henry L. Nourse, Arjun D. Rao, Michael J. Biercuk, Cornelius Hempel, Ivan Kassal, Ting Rei Tan   +12 more
openaire   +5 more sources

Recent advances in hydrogel—based wearable devices for sports monitoring and rehabilitation: Functional applications in training, injury prevention, and recovery

Polymer Testing
Hydrogels, owing to their superior softness, high water content, and excellent biocompatibility, are emerging as essential functional materials for next-generation wearable devices.
Nan Zhang, Qinghua Meng, Miaomiao Xiao, Chen Yang, Luxing Zhou, Hongshuai Leng, Chunyu Bao, Xuequan Feng   +7 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source