Results 61 to 70 of about 513,957 (266)

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

How does the job interview medium affect fairness perceptions and interview ratings? The mediating role of perceptions of social presence

BMC Psychology
The use of video-conference interviews (VIs) has increased substantially, especially with advances in technology and the emergence of COVID-19. Although prior research has suggested that VIs are associated with a lower perception of fairness by ...
Qin Gao, Yiyang Huang, Ruxin Yang, Ran Bian   +3 more
doaj   +1 more source

Vision-Capable LLMs in Microsurgery: A Blinded Comparison of Two AI Models with Expert Microsurgeons in the Appraisal of 200 Experimental Anastomoses

Medical Sciences
Background/Objectives: Objective end-product assessment of microsurgical anastomoses is intensive and partly subjective. Vision-capable large language models (LLMs) may enable standardized image-based scoring, but their agreement with expert assessment ...
Victor Esanu, Horatiu Alexandru Colosi, Stefan Agoston, Elisa Marziali, Radu Alexandru Ilies, Lorena Maria Hantig, Claudia Mihaela Paun, Alexandra Ioana Stoia, Alexia Onaciu, Iulia Cezara Pop, Cristina Maria Boznea, Ana-Maria Vartolomei, Farran Moustafa, Clemens Dirven, George Calin Dindelegan, Victor Volovici   +15 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

A scalable mental health intervention for depressive symptoms: evidence from a randomized controlled trial and large-scale real-world studies

npj Digital Medicine
Depressive symptoms pose a serious global threat to well-being, highlighting the need for scalable mental health interventions. E-mental health interventions offer promising population-level solutions, yet few are grounded in theory or tested on large ...
Jianjie Xu, Zhuo Rachel Han, Xiangxi Lv, Lu Chen, Ningning Mao, Mengyu Miranda Gao, Hanyi Zhang, Yueqin Hu, Shaozheng Qin, James J. Gross, Zhanjun Zhang   +10 more
doaj   +1 more source

Experimental and numerical simulations of stone blocks at the archeological site of Volubilis, Morocco [PDF]

MATEC Web of Conferences
This study aims to compare the results obtained experimentally on a stone sample used in the construction of the Triumphal Arch of Caracalla in the archaeological site of Volubilis with those obtained numerically by two implemented models: the Concrete ...
Sekkaki Mohamed, Naciri Khalil, Chaaba Ali   +2 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Experimental Simulation of Natural Heat Convection from Finned Vertical Plate with Different Inclinations

Al-Khawarizmi Engineering Journal, 2017
In this work an experimental simulation is made to predict the performance of steady-state natural heat convection along heated finned vertical base plate to ambient air with different inclination angles and configurations of fin array.
Saad Najeeb Shehab
doaj