Results 41 to 50 of about 513,957 (266)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Experimental Framework to Simulate Rescue Operations after a Natural Disaster
Journal of Computer Science and Technology, 2020 Computational simulation is a powerful tool for performance evaluation of computational systems. It is useful to make capacity planning of data center clusters, to obtain profiling reports of software applications and to detect bottlenecks.
Luis Veas Castillo +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Comparative analysis of flow patterns in planar and conical nozzles with narrow divergent angles [PDF]
FME TransactionsThe flow pattern in supersonic nozzles applied to the aerospace area is recurrently studied, since the geometrical profiles of the internal walls have a significant effect on the development of the flow regime.
Mírez Jorge +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Simulation and Experimental Results
, 2020 In this chapter we shall present the results obtained by the experimental and numerical campaign, apt to validate the proposed control and estimation methods presented in Chap. 4. In particular, we recall that we designed:two hierarchical controllers for the outputs; three dynamic feedback linearizing controllers for the output, and; a nonlinear ...
Tognon, Marco, Franchi, Antonio
openaire +2 more sources
AgricultureThe main approach for improving multiple traits simultaneously is the selection index. The most widely used selection indices are those based on factor analysis, which overcome statistical limitations such as multicollinearity and the reliance on ...
Wanessa Alves Lima Paiva +5 more
doaj +1 more source