Results 41 to 50 of about 2,254,759 (304)

Third Body Wear of an All-Polymer, PEEK-OPTIMA™ on Ultra-High-Molecular-Weight Polyethylene Total Knee Replacement

Bioengineering
Experimental wear simulation of a PEEK-OPTIMA™ polymer-on-UHMWPE total knee replacement has shown equivalent UHMWPE wear to conventional knee replacement materials (cobalt chrome-on-UHMWPE) when tested in a clean environment. The aim of this study was to
Raelene M. Cowie, Jens Schwiesau, Thomas M. Grupp, Adam Briscoe, Louise M. Jennings   +4 more
doaj   +1 more source

Bridging Scales in Alzheimer's Disease: Biological Framework for Brain Simulation With The Virtual Brain

Frontiers in Neuroinformatics, 2021
Despite the acceleration of knowledge and data accumulation in neuroscience over the last years, the highly prevalent neurodegenerative disease of AD remains a growing problem.
Leon Stefanovski, Leon Stefanovski, Jil Mona Meier, Jil Mona Meier, Roopa Kalsank Pai, Roopa Kalsank Pai, Roopa Kalsank Pai, Paul Triebkorn, Paul Triebkorn, Paul Triebkorn, Tristram Lett, Tristram Lett, Leon Martin, Leon Martin, Konstantin Bülau, Konstantin Bülau, Martin Hofmann-Apitius, Ana Solodkin, Anthony Randal McIntosh, Petra Ritter, Petra Ritter, Petra Ritter, Petra Ritter, Petra Ritter   +23 more
doaj   +1 more source

Estimate of average freeze-out volume in multifragmentation events [PDF]

, 2005
An estimate of the average freeze-out volume for multifragmentation events is presented. Values of volumes are obtained by means of a simulation using the experimental charged product partitions measured by the 4pi multidetector INDRA for 129Xe central ...
A. Chbihi, B. Borderie, B. Tamain, Bondorf, Borderie, Borderie, C. Volant, Charity, Chomaz, D'Agostino, D'Agostino, D'Agostino, D. Durand, D. Guinet, Das Gupta, Dean, Durand, Désesquelles, E. Bonnet, E. Galichet, E. Rosato, E. Vient, Frankland, Frankland, Friedman, G. Lanzalone, Goldhaber, Gonin, Gross, Hudan, J.D. Frankland, J.P. Wieleczko, Koonin, Lacroix, Lecolley, Lukasik, M. Parlog, M. Vigilante, M.F. Rivet, Marie, N. Le Neindre, Natowitz, O. Lopez, P. Lautesse, Parlog, Pouthas, R. Bougault, R. Dayras, Raduta, Richert, Rivet, S. Piantelli, Shlomo, Tabacaru, Vaz   +54 more
core   +3 more sources

Population model‐based analysis of the memory B‐cell response following belimumab therapy in the treatment of systemic lupus erythematosus

CPT: Pharmacometrics & Systems Pharmacology, 2023
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by B‐cell hyperactivity and breach of tolerance. Autoreactive memory B cells, which have a decreased activation threshold and the ability to survive in absence of antigen, are ...
Richard Dimelow, William R. Gillespie, Andre vanMaurik   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Effect analysis of a virtual simulation experimental platform in teaching pulpotomy

BMC Medical Education, 2022
Background The experimental teaching of pediatric dentistry is a bridge between theoretical study and clinical practice, and virtual simulation technology provides a new method of instruction.
Jiaxuan Lu, Xin Yang, Wei Zhao, Jiacheng Lin   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Straw resource performance and application potential assessment

Shenzhen Daxue xuebao. Ligong ban
Renewable straw resources have not been widely applied due to the lack of performance assessment. This study selected six representative characteristics of rural farmhouses for field research to understand the current state of rural housing and explore ...
CUI Dongjin, SU Chang, ZHU Mengye, ZHAO Haitian   +3 more
doaj   +1 more source

Optimal plot size for experimentation of common beans (Phaseolus vulgaris L.) in the northern region of Minas Gerais, Brazil

Revista de la Facultad de Ciencias Agrarias, 2021
The objective was to evaluate the minimum size of experimental plots for the common bean (Phaseolus vulgaris L.) using the modified maximum curvature method. The experiment consisted of a uniformity trial with the cultivar BRSFC-402 sown at a spacing
Bruno Vinícius Castro Guimarães, Abner José de Carvalho, Ignacio Aspiazú, Liliane Santana da Silva, Rafael Rogério Pereira da Silva, Amanda Maria Leal Pimenta, Marielly Maria Almeida Moura   +6 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source