Results 41 to 50 of about 530,929 (263)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Computational mechanics in science, applications and teaching [PDF]
Theoretical and Applied Mechanics, 2013 We express our opinion about the role of Computational Mechanics (CM) in science, applications and education. The presented thoughts rely on our experience gained by working over decades (first author in particular) in the field of CM. First, as
Kojić M., Filipović N.
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Lexicon-Enhanced LSTM With Attention for General Sentiment Analysis
IEEE Access, 2018 Long short-term memory networks (LSTMs) have gained good performance in sentiment analysis tasks. The general method is to use LSTMs to combine word embeddings for text representation.
Xianghua Fu +4 more
doaj +1 more source
A Model-Based Approach for Common Representation and Description of Robotics Software Architectures
Applied Sciences, 2022 Unlike conventional software, robotic software suffers from a lack of methods and processes that could systematize and facilitate development. Thus, the application of software engineering techniques is at the heart of current issues in robotics.
Valery Marcial Monthe +2 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Municipal AI integration: a structured approach
Frontiers of Urban and Rural PlanningThis research aims to develop a structured approach for implementing Artificial Intelligence (AI) in municipal governance. The study addresses three key questions: (1) What principles can be derived from existing AI implementation frameworks?
Lutz Eichholz
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Sentiment Analysis for Software Engineering Domain in Turkish
Sakarya University Journal of Computer and Information Sciences, 2020 The focus of this study is to provide a model to be used for the identification of sentiments of comments about education and profession life of software engineering in social media and microblogging sites.
Mansur Alp Toçoğlu
doaj +1 more source