Results 51 to 60 of about 1,784,727 (289)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Change Management Support for Large Software Systems [PDF]
, 1986 This technical report consists of three related papers in the area of management of source code changes for large software systems. Infuse: A Toolfor Automatically Managing and Coordinating Source Changes in Large Systems presents Infuse, a software ...
Kaiser, Gail E. +2 more
core +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Microservices and Machine Learning Algorithms for Adaptive Green Buildings [PDF]
, 2019 In recent years, the use of services for Open Systems development has consolidated and strengthened. Advances in the Service Science and Engineering (SSE) community, promoted by the reinforcement of Web Services and Semantic Web technologies and the ...
Alonso Montesinos, Joaquín Blas +6 more
core +1 more source
Analysing students' attitudes towards the learning of specialized software [PDF]
, 2014 In this article the situation of teaching in engineering courses using specialized software support is evaluated and analysed.The statistics courses in engineering often come off as element of formal exposure to statistical analysis and research methods.
Rocha, Ana Maria A. C. +1 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Automotive Engineering Drawing Learning: Effective Online Learning Using Autocad Application
Journal of Education Technology, 2021 Learning outcomes are not satisfactory and student learning motivation is low. As a result, students cannot fully master the competency of automotive engineering drawings which are learning outcomes..
Farid Mutohhari +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Lexicon-Enhanced LSTM With Attention for General Sentiment Analysis
IEEE Access, 2018 Long short-term memory networks (LSTMs) have gained good performance in sentiment analysis tasks. The general method is to use LSTMs to combine word embeddings for text representation.
Xianghua Fu +4 more
doaj +1 more source