Results 51 to 60 of about 530,929 (263)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Educational Application of Flow3D Software for Turbulent Modeling in 3D Simulation of Hydraulic Jump in Stilling Basin with Concrete Baffles [PDF]
Fanāvarī-i āmūzish, 2008 In this paper, hydraulic jump which is one of the effective means of energy dissipation of supercritical flow in hydraulic engineering is simulated using Flow 3D software.
S.R. Sabbagh Yazdi +2 more
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Jurnal Teknologi Pendidikan, 2015 This study aimed to develop a hypertext-based learning media for data com- munication and computer networks in Subak concept oriented. The method used an R & D to design development Dick & Carey model of the modi ed software with a special method ...
Ketut Agustini
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
UniMAP e-Lab for Electrical Engineering Technology: Future Online Laboratory Classes
MATEC Web of Conferences, 2016 This paper will describe a proposed design and approaches to the future provision of laboratory experience using communication and control technology.
Daud Mohd Hisam, Razali Zol Bahri
doaj +1 more source
Numerical analysis of a reinforced concrete frame with masonry infill under seismic loading [PDF]
Constructii: Journal of Civil Engineering Research, 2021 The paper is mainly focused on the investigation of the seismic response of reinforced concrete frames with masonry infills. Numerical results obtained with a strut model built in ETABS 2016 software are compared with the experimental results obtained on
Mohamed ISSA +3 more
doaj
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source