Results 131 to 140 of about 9,415,293 (298)

Biomechanics of Hollow Organs: Experimental Testing and Computational Modeling. [PDF]

Bioengineering (Basel), 2023
Fontanella CG, Carniel EL.
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Experimental testing of irradiated engine oil using an e-beam. [PDF]

Sci Rep, 2023
Zachar M, Furch J.
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Load-Bearing Capacity and Damages Morphology of Joints of AAC Masonry Walls Subjected to Shearing with Bending

Architecture, Civil Engineering, Environment
The article presents the results of original research on wall connections made of autoclaved aerated concrete subjected to shear with bending. The shape of the test element and the test stand layout were innovatively selected based on the author’s ...
GALMAN Iwona, BAJZECEROVÁ Viktória, KUŠNÍR Štefan, JASIŃSKI Radosław   +3 more
doaj   +1 more source

Experimental and Numerical Verification of Continuous Carbon-Fibre Additively Manufactured Structures

Modelling
This study investigates the mechanical behaviour of continuous carbon-fibre-reinforced additively manufactured composite structures aimed at applications in aeronautical structures, through a combination of experimental testing and numerical simulation ...
Ivica Smojver, Darko Ivančević, Fran Ušurić, Moritz Kuhtz, Andreas Hornig   +4 more
doaj   +1 more source

FREEDA: An automated computational pipeline guides experimental testing of protein innovation. [PDF]

J Cell Biol, 2023
Dudka D, Akins RB, Lampson MA.
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Experimental and Numerical Investigation of Additively Manufactured Continuous Fibre-Reinforced Composites for UAV Structures

Applied Sciences
Additive manufacturing of continuous fibre-reinforced composites enables lightweight and structurally efficient solutions for aerospace applications. In this work, specimens were fabricated with an Anisoprint Composer A3® printer using carbon fibres and ...
Ivica Smojver, Darko Ivančević, Fran Ušurić, Luka Brenko   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source