Results 1 to 10 of about 12,685,705 (296)

Mechanism of Sijunzi Decoction in the treatment of colorectal cancer based on network pharmacology and experimental validation.

open access: yesJournal of Ethnopharmacology, 2022
ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi Decoction(SJZD), as a famous classical prescription for the treatment of colorectal cancer(CRC) in the traditional Chinese medicine (TCM), has achieved good curative effects in clinical practice.
Luorui Shang   +8 more
semanticscholar   +1 more source

Immunohistochemical Demonstration of the pGlu79 α-Synuclein Fragment in Alzheimer’s Disease and Its Tg2576 Mouse Model

open access: yesBiomolecules, 2022
The deposition of β-amyloid peptides and of α-synuclein proteins is a neuropathological hallmark in the brains of Alzheimer’s disease (AD) and Parkinson’s disease (PD) subjects, respectively. However, there is accumulative evidence that both proteins are
Alexandra Bluhm   +6 more
doaj   +1 more source

In Silico Identification and Experimental Validation of Distal Activity-Enhancing Mutations in Tryptophan Synthase

open access: yesACS Catalysis, 2021
Allostery is a central mechanism for the regulation of multi-enzyme complexes. The mechanistic basis that drives allosteric regulation is poorly understood but harbors key information for enzyme engineering.
Miguel A. Maria-Solano   +4 more
semanticscholar   +1 more source

Pepper Fruit Extracts Show Anti-Proliferative Activity against Tumor Cells Altering Their NADPH-Generating Dehydrogenase and Catalase Profiles

open access: yesAntioxidants, 2023
Cancer is considered one of the main causes of human death worldwide, being characterized by an alteration of the oxidative metabolism. Many natural compounds from plant origin with anti-tumor attributes have been described.
Marta Rodríguez-Ruiz   +8 more
doaj   +1 more source

Therapeutic Effects of Naringin in Rheumatoid Arthritis: Network Pharmacology and Experimental Validation

open access: yesFrontiers in Pharmacology, 2021
Rheumatoid arthritis is a chronic autoimmune disease characterized by persistent hyperplasia of the synovial membrane and progressive erosion of articular cartilage.
Yirixiati Aihaiti   +7 more
semanticscholar   +1 more source

Is γKLS-generalized statistical field theory complete?

open access: yesPhysics Letters B, 2023
In this Letter we introduce some field-theoretic approach for computing the critical properties of γKLS-generalized systems undergoing continuous phase transitions, namely γKLS-statistical field theory.
P.R.S. Carvalho
doaj   +1 more source

Predictive analytical modelling and experimental validation of processing maps in additive manufacturing of nitinol alloys

open access: yes, 2021
Nitinol (NiTi) shape memory alloys fabricated by Laser Powder Bed Fusion ( L -PBF) Additive Manufacturing (AM) have attracted much attention in recent years, as compared with conventional manufacturing processes it allows to produce Nitinol parts with ...
Jia Zhu   +5 more
semanticscholar   +1 more source

Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro

open access: yesMolecules, 2020
Alzheimer’s disease (AD) and Parkinson’s disease (PD), including dementia with Lewy bodies (DLB), account for the majority of dementia cases worldwide.
Janett Köppen   +14 more
doaj   +1 more source

miRNA Targets: From Prediction Tools to Experimental Validation

open access: yesMethods and Protocols, 2020
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression in both animals and plants. By pairing to microRNA responsive elements (mREs) on target mRNAs, miRNAs play gene-regulatory roles, producing remarkable changes in several ...
G. Riolo   +3 more
semanticscholar   +1 more source

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