Results 61 to 70 of about 286,000 (316)

Experimental verification of new neutron absorbers concepts

, 2023
The presented paper describes experimental verification of the fixed neutron absorber for VVER-1000 fuel assemblies in the LR-0 zero-power reactor. This research determines the critical state parameters for fuel without these absorbers and for fuel with ...
Jiřičková, Jana, Lovecký, Martin, Závorka, Jiří, Škoda, Radek   +3 more
core   +1 more source

Network pharmacology analysis of Lanatoside C: molecular targets and mechanisms in the treatment of ulcerative colitis

Frontiers in Molecular Biosciences
IntroductionUlcerative colitis (UC) is a chronic and progressive inflammatory disease of the intestines, marked by recurrent inflammation along the digestive tract, leading to symptoms such as bloody diarrhea and weight loss, severely impacting patients’
Wenjing Zhu, Zhengjie Zhang, Xinyuan Wang   +2 more
doaj   +1 more source

A 3D QSAR Study of Betulinic Acid Derivatives as Anti-Tumor Agents Using Topomer CoMFA: Model Building Studies and Experimental Verification

Molecules, 2013
Betulinic acid (BA) is a natural product that exerts its cytotoxicity against various malignant carcinomas without side effects by triggering the mitochondrial pathway to apoptosis. Betulin (BE), the 28-hydroxyl analog of BA, is present in large amounts (
Yang Wang, Weimin Ding, Xiufeng Yan, Miao Sun, Shaman Luo, Tao Xu, Yibo Cao   +6 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Experimental Verification of a Battery Energy Storage System for Integration with Photovoltaic Generators [PDF]

, 2017
This paper presents the experimental verification of a 2 kW battery energy storage system (BESS). The BESS comprises a full-bridge bidirectional isolated dc-dc converter and a PWM converter that is intended for integration with a photovoltaic (PV ...
Taghizadeh, S, Singh, R, Mekhilef, S, Tan, NML   +3 more
core   +1 more source

Experimental Verification of the Inverse Method of the Heat Transfer Coefficient Calculation

Energies, 2020
The purpose of this work is to formulate a method which can be used to solve nonlinear inverse heat conduction problems and to calculate the heat transfer coefficient distribution on the unknown boundary.
Piotr Duda, Mariusz Konieczny
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Exploring the effect and mechanism of fucoidan on liver cancer depending on network pharmacology and experimental verification

Frontiers in Chemistry
ObjectiveThis research investigates the anti-liver cancer mechanisms of fucoidan by integrating network pharmacology analysis, molecular docking, and in vitro validation.MethodsPotential targets of fucoidan were first predicted using the ...
Xinghua Li, Xinghua Li, Chengyu Yang, Liwei Wang, Ihsan Ullah, Xinyue Liu, Chunqi Feng, Qi Liu   +7 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source