Results 61 to 70 of about 6,543,383 (305)

Network pharmacology analysis of Lanatoside C: molecular targets and mechanisms in the treatment of ulcerative colitis

Frontiers in Molecular Biosciences
IntroductionUlcerative colitis (UC) is a chronic and progressive inflammatory disease of the intestines, marked by recurrent inflammation along the digestive tract, leading to symptoms such as bloody diarrhea and weight loss, severely impacting patients’
Wenjing Zhu, Zhengjie Zhang, Xinyuan Wang   +2 more
doaj   +1 more source

A 3D QSAR Study of Betulinic Acid Derivatives as Anti-Tumor Agents Using Topomer CoMFA: Model Building Studies and Experimental Verification

Molecules, 2013
Betulinic acid (BA) is a natural product that exerts its cytotoxicity against various malignant carcinomas without side effects by triggering the mitochondrial pathway to apoptosis. Betulin (BE), the 28-hydroxyl analog of BA, is present in large amounts (
Yang Wang, Weimin Ding, Xiufeng Yan, Miao Sun, Shaman Luo, Tao Xu, Yibo Cao   +6 more
doaj   +1 more source

Abatacept for Prophylaxis of Acute and Chronic Graft‐Versus‐Host‐Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation—A Systematic Review and Meta‐Analysis of Cohort Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Graft‐versus‐host disease (GvHD) remains one of the most significant complications of hematopoietic stem cell transplantation (HSCT). Abatacept, a selective T‐cell costimulation modulator, is a relatively novel prophylactic agent, though pediatric data remain limited.
Matthijs D. Kruizinga, Anne B. Verbeek, Caroline A. Lindemans, Emilie P. Buddingh   +3 more
wiley   +1 more source

Experimental Verification of the Inverse Method of the Heat Transfer Coefficient Calculation

Energies, 2020
The purpose of this work is to formulate a method which can be used to solve nonlinear inverse heat conduction problems and to calculate the heat transfer coefficient distribution on the unknown boundary.
Piotr Duda, Mariusz Konieczny
doaj   +1 more source

Impact of Initial Treatment Setting on Survival in Relapsed Pediatric and AYA Bone Sarcomas: A Secondary Analysis of a Prospective Clinical Trial

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Outcomes in relapsed or refractory pediatric and AYA bone sarcomas remain poor, and the impact of early referral to specialized sarcoma centers on survival is unclear. Early centralization of care may improve local and systemic treatment quality, but evidence in this population is limited.
Justyna Antoniuk‐Majchrzak, Katarzyna Bilska, Tomasz Koziński, Jadwiga Węcławek‐Tompol, Dorota Sega‐Pondel, Radosław Chaber, Wanda Badowska, Katarzyna Rosłan, Hanna Koseła‐Paterczyk, Anna Raciborska   +9 more
wiley   +1 more source

Computer Aided Verification

, 2021
This open access two-volume set LNCS 12759 and 12760 constitutes the refereed proceedings of the 33rd International Conference on Computer Aided Verification, CAV 2021, held virtually in July 2021.

core   +2 more sources

Experimental Verification of Quark-Hadron Duality [PDF]

Physical Review Letters, 2000
A newly obtained sample of inclusive electron-nucleon scattering data has been analyzed for precision tests of quark-hadron duality.
Niculescu, I., Armstrong, C. S., Arrington, J., Assamagan, K. A., Baker, O. K., Beck, D. H., Bochna, C. W., Carlini, R. D., Cha, J., Cothran, C., Day, D. B., Dunne, J. A., Dutta, D., Ent, R., Filippone, B. W., Frolov, V. V., Gao, H., Geesaman, D. F., Gueye, P. L. J., Hinton, W., Holt, R. J., Jackson, H. E., Keppel, C. E., Koltenuk, D. M., Mack, D. J., Meekins, D. G., Miller, M. A., Mitchell, J. H., Mohring, R. M., Niculescu, G., Potterveld, D., Price, J. W., Reinhold, J., Segel, R. E., Stoler, P., Tang, L., Terburg, B. P., Van Westrum, D., Vulcan, W. F., Wood, S. A., Yan, C., Zeidman, B.   +41 more
openaire   +3 more sources

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

Exploring the effect and mechanism of fucoidan on liver cancer depending on network pharmacology and experimental verification

Frontiers in Chemistry
ObjectiveThis research investigates the anti-liver cancer mechanisms of fucoidan by integrating network pharmacology analysis, molecular docking, and in vitro validation.MethodsPotential targets of fucoidan were first predicted using the ...
Xinghua Li, Xinghua Li, Chengyu Yang, Liwei Wang, Ihsan Ullah, Xinyue Liu, Chunqi Feng, Qi Liu   +7 more
doaj   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source