Results 61 to 70 of about 521 (266)
Twenty Questions for Noël Arnaud
Studies in 20th & 21st Century Literature, 1986 Noël Arnaud, the president of the Ouvroir de Litterature Potentielle (Oulipo), discusses that institution's history, its literary aesthetic, and its goals.
Warren F. Motte Jr.
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Experimentalism in the Contemporary Relief Sculpture between Rebellion and Creation
Journal of Architecture, Art & Humanistic Science, 2017 The Experimental thought is regarded the core of the artistic experiment that personifies the thoughts and crystalizes feelings, even the imaginary, and appears to be in integration to emerge the new formative concepts and the new relations.
Yousef Ibrahim
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
O experimentalismo contra os idealismos nos escritos intermediários de Nietzsche [PDF]
Princípios, 2009 In this article we intent to show how called experimentalism is presented in the written of the second period of Nietzsche’s production (1878-1882), as a strategy to fight the “ideals” (that the result was a distancing from what Nietzsche understands as ...
Jelson Roberto de Oliveira
doaj
Postcolonial Trauma in William Trevor’s Anglo-Irish Big House Trilogy
Il Tolomeo, 2016 This article explores William Trevor’s Big House trilogy that is set against the backdrop of the early twentieth century Anglo-Irish tensions. By interweaving postcolonial theory and trauma studies, my investigation seeks to unveil the melancholic and
Monaco, Angelo
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source