Results 91 to 100 of about 514,337 (251)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Sulfenate anions as organocatalysts for benzylic chloromethyl coupling polymerization via C=C bond formation

Nature Communications, 2018
Polymerization reactions are often catalysed by metal compounds and hence there are concerns surrounding toxicity, cost and environmental friendliness.
Minyan Li, Simon Berritt, Carol Wang, Xiaodong Yang, Yang Liu, Sheng-Chun Sha, Bo Wang, Rui Wang, Xuyu Gao, Zhanyong Li, Xinyuan Fan, Youtian Tao, Patrick J. Walsh   +12 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Development of a predictive model for 1-year postoperative recovery in patients with lumbar disk herniation based on deep learning and machine learning

Frontiers in Neurology
BackgroundThe aim of this study is to develop a predictive model utilizing deep learning and machine learning techniques that will inform clinical decision-making by predicting the 1-year postoperative recovery of patients with lumbar disk herniation ...
Yan Chen, Yan Chen, Fabin Lin, Fabin Lin, Kaifeng Wang, Feng Chen, Ruxian Wang, Minyun Lai, Chunmei Chen, Chunmei Chen, Rui Wang, Rui Wang   +11 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

MINUTE BOOKS OF THE ANIMAL EXPERIMENTATION COMMITTEE / ANIMAL EXPERIMENTATION ETHICS COMMITTEE

, 1991
This record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/71226The
University of Melbourne. Animal Experimentation Ethics Committee
core  

The International C2 Journal, volume 4, number 3, 2010. Special Issue: Interagency Experimentation [PDF]

, 2010
Center for Network Innovation and Experimentation (CENETIX) PublicationBeginning in 2002, a team of Naval Postgraduate School researchers together with sponsors from the United States Special Operations Command (USSOCOM), and later joined by the Office ...
Netzer, David, Bordetsky, Alex
core   +2 more sources

A 1-km resolution dataset of affordability-constrained accessibility to elderly care facilities in China

Scientific Data
China’s rapid population aging presents profound challenges for equitable institutional elderly care. Traditional spatial accessibility metrics typically neglect affordability constraints, leading to systematic overestimation of effective access for low ...
Xiao Wang, Quanli Xu, Yu Wang, Fengzhi Wu   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source