Results 81 to 90 of about 514,337 (251)
City and Environment InteractionsThis study presents a fully automated pipeline for mapping Physiological Equivalent Temperature (PET) at high spatial resolution and simulating potential access to cooler paths for pedestrians in cities.
Deepank Verma +2 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Scientific ReportsMultiple lines of evidence indicate a northward expansion and year-round presence of fin whales especially around Svalbard, an area where highly variable Atlantic Water intrusion is changing the trophic community. Because fin whales are now documented in
Angela R. Szesciorka +5 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
A brief history of the NPS Field Experimentation program: Spanning STAN, TNT and JIFX [PDF]
, 2014 The NPS Field Experimentation Program was initiated in FY02 to provide an opportunity for NPS faculty and students to evaluate new technologies from their research in a field environment.
Oros, Carl L.
core +2 more sources
Transportation Research Interdisciplinary PerspectivesShade influences movement behavior of pedestrians, especially in urban extremes. Walking in the shade during urban heat conditions and strong sunlight helps regulate bodily temperatures and enhances thermal comfort for pedestrians.
Deepank Verma +2 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Exploratory experimentation and scientific practice: Metagenomics and the proteorhodopsin case [PDF]
, 2008 Exploratory experimentation and high-throughput molecular biology appear to have considerable affinity for each other. Included in the latter category is metagenomics, which is the DNA-based study of diverse microbial communities from a vast range of non-
O'Malley, Maureen
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source