Results 201 to 210 of about 1,148,036 (286)

Strengthening translational preclinical research through confirmatory multi-laboratory studies. [PDF]

Front Med (Lausanne)
Rotter SC, Arroyo-Araujo M, Drude NI, Pellegrini P, Kobold S, Richter GHS, Müller OJ, Bruder D, Riecken LB, Gerlach B, Schuler L, Salbach-Hirsch J, Dalloul I, Kühn S, Wilcke JC, Toelch U.   +15 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Retraction: Oncolytic virotherapy promotes radiosensitivity in soft tissue sarcoma by suppressing anti-apoptotic MCL1 expression. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Explaining the Slow Adoption of AI Innovations in Health Care: Network Analysis Approach. [PDF]

JMIR AI
Apell P, Locher S, Milde A, Eriksson H.
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Macro- and Micro-Level Behavioral Patterns in Simulation-Based Scientific Inquiry: Linking Processes to Performance Among Elementary Students. [PDF]

J Intell
Wang S, Hu A, Yuan L, Tian W, Xin T.
europepmc   +1 more source

The Impact of Continuous Flow Technology and Collaboration between Academia and Industry. [PDF]

JACS Au
Jamieson P, Bannon R, Cronly D, Smyth M, Wharry S, Moody TS, Lennon G, Baumann M.   +7 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Hybrid robust beamforming for enhanced multiple moving object detection with phased array scanning radar. [PDF]

Sci Rep
Islam SS, Hossain MS, Islam S, Hasan R.
europepmc   +1 more source