Results 81 to 90 of about 11,190,422 (282)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Effects of Size and Temperature‐Dependent Thermal Conductivity on the Cooling of Pyroclasts in Air
Geochemistry, Geophysics, Geosystems, 2018 The knowledge of the cooling time scales of pyroclasts, in conditions of free to forced convection, is of paramount importance in microtextural analysis, development of welded deposits, and in eruption column and pyroclast flow modeling.
Pranabendu Moitra +2 more
doaj +1 more source
, 2017 Precise prediction of the neutrino flux is a key ingredient to achieving the physics goals of accelerator-based neutrino experiments. In modern accelerator-based neutrino experiments, neutrino beams are created by colliding protons with a nuclear target.
Nagai, Yoshikazu
core
Transcendental Experience as a Thought Experiment [PDF]
HORIZON. Studies in Phenomenology, 2015 In my article I would like to discuss a topic concerning the idea of mental experience as an experiment in the transcendental philosophy. One of the main problems of the humanities is that one can see a big difference between two branches of knowledge: human sciences and «exact» sciences.
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
, 2006 The present status of double beta decay experiments are reviewed. The results of the most sensitive experiments, NEMO-3 and CUORICINO, are discussed. Proposals for future double beta decay experiments are considered.
+17 more
core +2 more sources
SOME EXPERIENCES WITH NEW EXPERIMENTS [PDF]
School Science and Mathematics, 1904 n ...
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Experiments on atmospheric processes [PDF]
, 1977 Spacelab technology is examined as applied to the observation of the earth's weather patterns, composition, thermodynamics, and kinematics. An atmospheric cloud physics laboratory and a geophysical fluid flow cell are individually outlined as planned ...
Vaughan, W. W.
core +1 more source