Results 111 to 120 of about 3,940,538 (284)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Designing an Estimation Pattern for Reliability of Launch Vehicle Structure with Bayesian Networks [PDF]
فصلنامه علوم و فناوری فضایی, 2012 Failures identification of vital and sensitive products and their reliability estimation, before applying affects design improvement of them. On the other hand, because of lack of data,reliability estimation of some systems such asspace products is hard ...
S. M. M. Sharifi +3 more
doaj
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Implicit learning of expert chess knowledge [PDF]
, 2003 This article discusses how CHREST's mechanisms lead to the implicit learning of a large number of chunks, which underpin (expert) behaviour in a number of domains.
Gobet, F
core
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Expert system technology [PDF]
The expert system is a computer program which attempts to reproduce the problem-solving behavior of an expert, who is able to view problems from a broad perspective and arrive at conclusions rapidly, using intuition, shortcuts, and analogies to previous ...
Prince, Mary Ellen
core +1 more source
Applications of Expert Systems in Transport [PDF]
, 1986 BACKGROUND Experienced judgement and specialist knowledge are essential to the proper specification, understanding and interpretation of data and computer analyses.
Bonsall, P.W., Kirby, H.R., Kwan, R.S.
core
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
What is an expert mathematics teacher? [PDF]
, 2012 In Portugal, the introduction of new mathematics curriculum for basic education generated new images about the activity of the mathematics classroom and about the role of the teacher, based on the notions of “explorations” and “discussion”.
Ponte, João Pedro da
core