Results 191 to 200 of about 1,589,292 (261)

Expert consensus on urate‑lowering therapy for high‑risk hyperuricemia (2026 edition). [PDF]

Chin Med J (Engl)
Zhu X, Mo Y, Duan L, Qing Y, Dai L, Zhang Z, Zhao Y, Zou H.   +7 more
europepmc   +1 more source

Deep Learning‐Driven Discovery and Engineering of an Efficient PETase for Depolymerization and Detoxification of PET Microplastics Under Physiological Conditions

Advanced Science, EarlyView.
A deep learning–driven pipeline mining 246 million protein sequences uncovers AhPETase, an evolutionarily distinct PET hydrolase. Engineered variant AhPETaseM1 degrades post‐consumer PET microplastics under physiological conditions and reverses microplasticinduced cytotoxicity in human lung and colon cells, establishing enzymatic microplastic ...
Yuxuan Wang, Shijie He, Yuheng Chang, Sheng Mao, Jianan Canal Li, Binbin Chen, Hongxun Gao, Mingchun Xu, Chenxu Liu, Yajie Wang   +9 more
wiley   +1 more source

Chinese expert consensus on the treatment and diagnosis of moyamoya disease and moyamoya syndrome (2024). [PDF]

Stroke Vasc Neurol
Ni W, Su J, Fei Y, Gu Y, Mao Y, Wang S, Consensus Expert Committee Members.   +6 more
europepmc   +1 more source

Advances in Se Wide‐Bandgap Photovoltaics and TexSe1‐x SWIR Photodiodes

Advanced Science, EarlyView.
In this review, fundamental properties and current challenges in Se photovoltaics (PVs) for tandem and indoor PVs and TexSe1‐x alloys for short wave infrared photodiodes are discussed. A case is made for the practicality of elemental chalcogenide optoelectronics, and a pathway toward resolving the key challenges in these respective technologies is ...
Adam D. Alfieri, Deep Jariwala
wiley   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

The expert consensus document on minimally invasive upper lobectomy for lung cancer in China. [PDF]

J Thorac Dis
Wu L, Mei L, Zhao J, Shen C, Wu W, Xu S, Xiu Y, Liu W, Zhao G, Xue Z, Xie D, Xie L, Huang H, Liang N, Xian L, Deng B.   +15 more
europepmc   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Chinese expert consensus on the clinical application of sodium-glucose cotransporter 2 inhibitors in patients with chronic kidney disease

Chinese Medical Journal
The Expert Group of Chinese Expert Consensus on the Clinical Application of Sodium-glucose Cotransporter 2 Inhibitors in Patients with Chronic Kidney Disease, Yuanyuan Ji   +1 more
doaj   +1 more source

Pharmacological treatment of schizophrenia: Japanese Expert Consensus 2025. [PDF]

Schizophrenia (Heidelb)
Takekita Y, Tani H, Kawamata Y, Katsuki A, Muraoka H, Ochi S, Tagata H, Sawada K, Nishi A, Hattori S, Kikuchi T, Baba H, Kato M, Watanabe K, Inada K, Yasui-Furukori N, Sakurai H, Iga JI.   +17 more
europepmc   +1 more source