Results 201 to 210 of about 1,589,292 (261)

Optimized Cas9‐Enriched Nanopore Sequencing and Analysis Workflow for Clinical Diagnosis of Repeat Expansion Disorders

Advanced Science, EarlyView.
An optimized Cas9‐enriched nanopore sequencing workflow, combined with STRiker, enables simultaneous analysis of disease‐associated STR loci from patient blood. The nCATS–STRiker workflow detects repeat expansions, de novo repeat motifs, interruption patterns, and methylation in a single assay, improving the genetic diagnosis of previously undiagnosed ...
Seungbok Lee, Chanju Jung, Minjeong Kim, Narae Kim, Gue‐Ho Hwang, Soon‐Tae Lee, Kon Chu, Sang Kun Lee, Han‐Joon Kim, Jong‐Hee Chae, Sangsu Bae, Jangsup Moon   +11 more
wiley   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

Asia-Pacific expert consensus on robotic-assisted hip and knee arthroplasty. [PDF]

Arthroplasty
Zhang G, Zhou Y, Chen Y, Budhiparama NC, Yan CH, Lim SJ, Liow LMH, Sugano N, Tang A, Cai H, van Bavel D, Chai W, Chan PK, Fang X, Feng E, Fu H, Hiranaka T, Zhou Z, Kim KI, Kurmis A, Li H, Liu D, Liu X, Lustig S, Mao X, Matsumoto T, Ni M, Ong M, Park SE, Qian W, Shao H, Singh C, Tang H, Minoda Y, Wu H, Xie J, Yeo SJ, Zhang X, Tanavalee A, Cao L, Yoo MC, Wang Y.   +41 more
europepmc   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Core Self-Reported Variables for Next-Generation Colorectal Cancer Risk Prediction: An International Expert Consensus Study. [PDF]

Cancer Med
Dubois H, Torbjörnsson E, Norrbom J, Hubbard A, Enskär M, Phillips RV, van der Laan M, Blom J.   +7 more
europepmc   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

Diabetic sarcopenia in clinical practice: expert consensus and usability evaluation of a novel screening and diagnostic algorithm. [PDF]

Front Nutr
Sanz-Paris A, Tarazona-Santabalbina FJ, Gómez JC, de Luis Román D, García-Almeida JM, Garrachón-Vallo F, López-Gómez JJ, Guzmán-Rolo G, García-Luna PP.   +8 more
europepmc   +1 more source

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

Methodological Framework for Global Expert Consensus on Musculoskeletal Infection: Establishing the ICM 2025 Recommendations. [PDF]

Global Spine J
Muthu S, Gurusamy G, Parvizi J, Rajasekaran S.   +3 more
europepmc   +1 more source

Longitudinal Multifrequency MR Elastography Reveals Biomechanical Signatures of Progression in a Translational Liver Tumor Model

Advanced Science, EarlyView.
Longitudinal multifrequency magnetic resonance elastography (mMRE) performed on a clinical 3 Tesla magnetic resonance imaging system reveals early biomechanical alterations during liver tumor progression in a translational VX2 model. Changes in tumor stiffness and viscosity precede diffusion‐related alterations and are associated with extracellular ...
Justus Ramtke, Friederike Hesse, Lasse Noack, Justus Klockner, Yubei He, Yu Liu, Yanglei Wu, Robin Schmidt, Selma Saclier, Salma A. S. Abosabie, Tom Meyer, Richard Ruppel, Nikolaus Berndt, Michael Mülleder, Eyk Schellenberger, Nicola Beindorff, Dominik N. Müller, Ingolf Sack, Jing Guo, Shraga Nahum Goldberg, Lynn Jeanette Savic   +20 more
wiley   +1 more source