Results 211 to 220 of about 1,589,292 (261)

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Mild Cognitive Impairment Diagnosis and Care Algorithms and the Role of Digital Interventions: Expert Consensus. [PDF]

CNS Neurosci Ther
Kandiah N, Chan YF, Dasig D, Dominguez J, Koh KC, Lim SC, Ong PA, Raya-Ampil E, Seet RCS, Senanarong V, Tan KM, Tan MP, Thắng TC, Trang TM, Turana Y, Wei C, Ihl R.   +16 more
europepmc   +1 more source

A Real‐Data‐Driven Framework for Evaluating Differential Transcript Usage Methods Across Long‐Read Bulk, Single‐Cell, and Spatial Transcriptomics

Advanced Science, EarlyView.
Grounded in real biological RNA‐seq data, the framework benchmarks ten differential transcript usage (DTU) methods across short‐read bulk, long‐read bulk, long‐read single‐cell, and long‐read spatial transcriptomics. By integrating reference transcript sets with ranked DTU results, the Transcript Set Enrichment Score (TSES) identifies data‐type ...
Chenxing Zhang, Jun Liu, Qi Zhao, Huilong Yin, Angang Yang, Minhua Zheng, Rui Zhang   +6 more
wiley   +1 more source

Expert consensus on the reporting and clinical follow up of individuals with incidentally discovered germline RET variants in the UK. [PDF]

Endocr Relat Cancer
Hanson H, Snape K, Dias RP, Park SM, Shaikh MG, Kurzawinski TR, Izatt L, Patel KA, Korbonits M, Casey RT.   +9 more
europepmc   +1 more source

The MoSR‐MoDde1 Regulatory Axis: A Novel Determinant of DMI Sensitivity and a Target for Sustainable Rice Blast Control

Advanced Science, EarlyView.
The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Fan‐Zhu Meng, Wen‐Kai Wei, Meng‐Yao Wu, Min‐Zheng Cai, Yu‐Fu Wang, Li Zhao, Shuai Meng, Liang‐Fen Yin, Guido Schnabel, Wei‐Xiao Yin, Chao‐Xi Luo   +10 more
wiley   +1 more source

International expert consensus on transdermal drug delivery technologies in dermatology. [PDF]

JAAD Int
Zhu J, Li Y, Wang X, Xiang L, Röcken M, Piguet V, Verma S, Thaçi D, Li C, Chen X, Zhu M, Miao X, Wang H, Zhou C, Ding Y, Xie J, Shi Y, Goldman MP, Hao F, Mu Q, Man X, Chung WH, Wang X, Xiao R, Yu N, Chen A, Zhu J, Cui Y, Ma L, Yin P, Bu W, Yang L, Li J, Gao X, Tao J.   +34 more
europepmc   +1 more source

Granzyme B PET Imaging Reveals Lgmn+ Macrophage‐Mediated Immune Evasion and Guides Immunotherapy in EGFR‐TKI‐Resistant NSCLC

Advanced Science, EarlyView.
Graphical illustration of 68Ga‐GZB PET/CT imaging reveals immune dynamics post‐EGFR‐TKI resistance in NSCLC; Lgmn+ macrophages‐derived Lgmn‐containing extracellular vesicles inhibit glycolysis, induce CD8+ T cell exhaustion, and targeting Lgmn restores immunotherapy sensitivity.
Dongliang Wang, Wenqin Luo, Qiufang Liu, Wenxuan Tang, Bin Zhu, Jiwei Chen, Qian Zhou, Shuang Tang, Xiaoping Xu, Shaoli Song   +9 more
wiley   +1 more source

National expert consensus recommendations on influenza vaccination in Saudi Arabia (2025). [PDF]

J Family Community Med
Al Amir A, Alshehri A, Al Barrak A, Farahat F, Joharjy H, Omran H, Elawad K, Alnamnakani M, Alshamrani M, Al-Thaqafy MS, AlSherbeeni N, Alzomor O, Alameer R, Alshahrani NZ.   +13 more
europepmc   +1 more source