Results 121 to 130 of about 9,644,403 (292)

Code of practice on the fluoridation of drinking water [PDF]

open access: yes, 2007
Irish Expert Body on Fluorides and Health ...
Irish Expert Body on Fluorides and Health
core  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Complicidad empresarial y responsabilidad legal, Volumen 2. Derecho penal y crímenes internacionales en "Report of the ICJ Expert Legal Panel on Corporate Complicity in International Crimes"

open access: yesRelaciones Internacionales, 2009
"Complicidad empresarial y responsabilidad legal", Volumen 2. Derecho penal y crímenes internacionales en "Report of the ICJ Expert Legal Panel on Corporate Complicity in International Crimes".
- Comisión Internacional de Juristas
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Current management of Duchenne muscular dystrophy in the Middle East: expert report. [PDF]

open access: yesNeurodegener Dis Manag, 2019
Jumah MA   +18 more
europepmc   +1 more source

WHO Expert Committee on Specifications for Pharmaceutical Preparations : forty-first report

open access: yes, 2007
"The WHO Expert Committee on Specifications for Pharmaceutical Preparations met in Geneva from 16 to 20 October 2006"--Introduction156 ...
WHO Expert Committee on Specifications for Pharmaceutical Preparations. Meeting (2006 : Geneva, Switzerland)   +1 more
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

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