Results 81 to 90 of about 480,826 (310)
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Challenges in Diabetic Macular Edema Management: An Expert Consensus Report
Clinical Ophthalmology, 2021 Patricia Udaondo,1 Alfredo Adan,2 Luis Arias-Barquet,3 Francisco J Ascaso,4 Francisco Cabrera-López,5 Verónica Castro-Navarro,6 Juan Donate-López,7 Alfredo García-Layana,8 Francisco Javier Lavid,9 Mariano Rodríguez-Maqueda,10 José María Ruiz-Moreno11 ...
Udaondo P +10 more
doaj
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Expert report to the infected blood inquiry: health economics [PDF]
, 2023 Morgan, Myfanwy +6 more
core +1 more source
Verification of Cucumber Expert System [PDF]
, 2003 Verification of the cucumber expert systems.
Climate Change Information Center & Renewable Energy & Expert Systems +2 more
core
Final Synthesis Report on Social Inclusion: ESF Expert Evaluation Network
, 2012 This third Synthesis Report from the ESF Expert Evaluation Network assesses ESF-supported Social Inclusion actions across the 27 Member States on the basis of country ...
McGregor, Alan, Sutherland, Victoria
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Some thoughts about a continuous debate
, 2013 Summary report for the E15 Expert Group on Agriculture and Food Security. This paper is an input to the work of the “Expert Group on Agriculture, Trade and Food Security Challenges” as part of the E-15 Initiative of the International Center for Trade and
Díaz-Bonilla, Eugenio +1 more
core