Results 91 to 100 of about 480,826 (310)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The rapid assessment workshop to elicit expert consensus to inform the development of the Great Barrier Reef Outlook Report 2019 [PDF]
, 2019 The Outlook consensus workshop was organised and convened by the Great Barrier Reef Marine Park Authority (GBRMPA) in Townsville on 28 May to 1 June 2018.
Harper, T.W.
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Expert Systems - A Natural History
, 1989 This paper examines the origins, current state and future prospects for expert systems. The origins are traced from the schism with classic Artificial Intelligence. The characteristics of early expert systems are described and contrasted with more recent
Shadbolt, N. R.
core
One Report, Multifaceted Views: Multi-Expert Rewriting for ECG Interpretation
Applied SciencesData scarcity is a significant barrier to developing high-performing AI models for medical text classification. To improve stroke prediction from electrocardiogram (ECG) interpretations reports where training data are scarce, we propose a novel data ...
Yu-Hyeon Kim, Chulho Kim, Yu-Seop Kim
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
PUBLISHABLE SUMMARY EURO-EXPERT CONSOLIDATOR GRANT (2016 -2023)
, 2023 of the context and overall objectives of the project EURO-EXPERT focused on cultural expertise in Europe to ensure fair and inclusive justice in diverse societies.
Holden, Livia
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Prolog and expert systems [PDF]
, 1987 The first part of the thesis provides an introduction to the logic programming language Prolog and some areas of current research. The use of compilation to make Prolog faster and more efficient is studied and a modified representation for complex ...
Davies, Peter Leslie
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source