Results 131 to 140 of about 23,690,640 (370)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Speech Therapy Based on Expert System

open access: yesAdvances in Electrical and Computer Engineering, 2009
In this paper the design and implementation of an expert speech therapy system is presented. A brief presentation of involved speech therapy process is made. Also the base for designing and implementations of this system is presented too.
ZAHARIA, M. H., LEON, F.
doaj   +1 more source

Competence assessment as an expert system for human resource management: A mathematical approach [PDF]

open access: yesExpert systems with applications, 2017
M. Bohlouli   +5 more
semanticscholar   +1 more source

CD44v, S1PR1, HER3, MET and cancer‐associated amino acid transporters are promising targets for the pancreatic cancers characterized using mAb

open access: yesFEBS Open Bio, EarlyView.
Novel mAbs could detect cancer‐associated membrane proteins on various type of pancreatic ductal adenocarcinomas (PDAC) by flow cytometry with viable PDAC cells and by immunohistochemistry with PDAC tissues. Results of protein expression were substantiated by mRNA expression by The Cancer Genome Atlas.
Takashi Nakano   +16 more
wiley   +1 more source

Cluster-Driven Expert Pruning for Mixture-of-Experts Large Language Models [PDF]

open access: yesarXiv
Mixture-of-Experts (MoE) architectures have emerged as a promising paradigm for scaling large language models (LLMs) with sparse activation of task-specific experts. Despite their computational efficiency during inference, the massive overall parameter footprint of MoE models (e.g., GPT-4) introduces critical challenges for practical deployment ...
arxiv  

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

open access: yesFEBS Open Bio, EarlyView.
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang   +11 more
wiley   +1 more source

What Makes An Expert? Reviewing How ML Researchers Define "Expert" [PDF]

open access: yesarXiv
Human experts are often engaged in the development of machine learning systems to collect and validate data, consult on algorithm development, and evaluate system performance. At the same time, who counts as an 'expert' and what constitutes 'expertise' is not always explicitly defined.
arxiv  

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