Results 51 to 60 of about 25,120,416 (357)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Evaluation of Artificial Intelligence Effectiveness in Detection of Lumbosacral Spine Degenerative Diseases

open access: yesВестник рентгенологии и радиологии
Objective: comparative evaluation of output data of a set of trained convolutional neural network (CNN) models and interpretation of pathological changes in lumbar spine by radiologists during magnetic resonance imaging.Material and methods. More than 12,
N. В. Nudnov   +11 more
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

Designing a tool/platform for developing expert systems

open access: yesTaikomieji Moksliniai Tyrimai
The article analyzes the company's need to create a prototype for the development of expert systems. Expert systems and tools for their creation were examined, functions and software for the creation of an expert system that met the needs of the company ...
Donatas Daugirdas, Karolis Paliliūnas
doaj   +1 more source

Expert Finding System [PDF]

open access: yesInternational Journal of Trend in Scientific Research and Development, 2018
Current education system turning to the digital learning technique. E learning is one of the most widely used methods for the education. E learning gives experience as individual learning at any time as well as anywhere, so user get more interest, flexibility at learning.
Nalawade Priyanka   +4 more
openaire   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

open access: yesMolecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo   +8 more
wiley   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

open access: yesMolecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton   +17 more
wiley   +1 more source

Declaración medioambiental [PDF]

open access: yes
EMASNom anterior: Expert Components, S.A. (1991-2004)Resultat de la fusió l'agost de 2004 de: EXPERT Automotive Corporation, S.L., EXPERT Components, S.A. i EXPERT Components Pamplona, S.A.Fabricació d'altres productes de matèries plàstiques.
Automotive Modular Systems, S.L   +2 more
core  

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

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