Results 51 to 60 of about 220,602 (307)

Exploring the solar paradigm to explain stellar variability [PDF]

, 2021
Nina-Elisabet Nèmec
openalex   +1 more source

Explainability-driven adversarial robustness assessment for generalized deepfake detectors

EURASIP Journal on Information Security
The capabilities of generative models to produce high-quality fake images require deepfake detectors to be accurate and have strong generalization performance.
Lorenzo Cirillo, Andrea Gervasio, Irene Amerini   +2 more
doaj   +1 more source

Integrated Evolutionary Learning: An Artificial Intelligence Approach to Joint Learning of Features and Hyperparameters for Optimized, Explainable Machine Learning

Frontiers in Artificial Intelligence, 2022
Artificial intelligence and machine learning techniques have proved fertile methods for attacking difficult problems in medicine and public health. These techniques have garnered strong interest for the analysis of the large, multi-domain open science ...
Nina de Lacy, Michael J. Ramshaw, J. Nathan Kutz   +2 more
doaj   +1 more source

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Toward Explainable Facial Expression Recognition Using Face Action Units: XFER-AU

IEEE Access
Face expression recognition (FER) has been extensively explored by the research community, with comparisons between different FER models typically relying on accuracy metrics.
Tanmay Tulsidas Verlekar, Arnav Goyal, Paulo Lobato Correia   +2 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Pre Hoc and Co Hoc Explainability: Frameworks for Integrating Interpretability into Machine Learning Training for Enhanced Transparency and Performance

Applied Sciences
Post hoc explanations for black-box machine learning models have been criticized for potentially inaccurate surrogate models and computational burden at prediction time.
Cagla Acun, Olfa Nasraoui
doaj   +1 more source