Results 151 to 160 of about 2,581,635 (319)

Effects of Implicit and Explicit Focus on Form on L2 Acquisition of the English Passive

, 2019
Ji-Yung Jung
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Explicit form of the Bayesian posterior estimate of a quantum state under the uninformative prior [PDF]

, 2014
V. S. Shchesnovich
openalex   +1 more source

Explicit form of quaternion modular embeddings

, 1995
Let \(\mathbb{B}\) be an indefinite quaternion algebra over \(\mathbb{Q}\), and let \({\mathcal O}\) be an Eichler order of \(\mathbb{B}\). If \(Nr\) denotes the reduced norm of \(\mathbb{B}\), then \(\Gamma = \{\gamma \in {\mathcal O} \mid Nr (\gamma) = 1\}\) is a discrete subgroup of \(\mathbb{B}^{(1)}\cong SL_2 (\mathbb{R})\), and the quotient ...
openaire   +3 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Medical expertise as hybrid expertise: a proposal for the articulation of medical knowledge. [PDF]

Philos Ethics Humanit Med
Cuevas-Badallo A, Torres González O.
europepmc   +1 more source

Evaluating the Effectiveness of Deductive and Inductive Form-Focused In- struction on Iranian EFL Learners' Implicit and Explicit Knowledge of Non- Generic Definite Article [PDF]

, 2013
Majid Ghorbani, Hossein Younesi
openalex  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

The challenge of explicit learning in life skill education. [PDF]

NPJ Sci Learn
Piehlmaier DM, Warmath D.
europepmc   +1 more source