Results 91 to 100 of about 1,962,077 (344)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Contrastivism and anti-individualism part II: a further response to Aikin and Dabay [PDF]
, 2015 In this reply paper, I defend my original claim that contrastive self-knowledge entails anti-individualism against an alleged counter-argument from Aikin and Dabay.
Sawyer, Sarah
core +1 more source
, 2009 This entry explores the differences between tacit and explicit knowledge. Tacit knowledge is defined as a form of knowing that cannot be expressed. Organizational theory has been particular concerned with tacit knowledge as a part of an effort to identify and utilize the unique knowledge that is distinctive to successful organizations.
openaire +2 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
A Hybrid Structure Learning Algorithm for Bayesian Network Using Experts’ Knowledge
Entropy, 2018 Bayesian network structure learning from data has been proved to be a NP-hard (Non-deterministic Polynomial-hard) problem. An effective method of improving the accuracy of Bayesian network structure is using experts’ knowledge instead of only using
Hongru Li, Huiping Guo
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Mokslas: Lietuvos Ateitis, 2011 Optimization of building maintenance expenditure becomes really an urgent issue in Lithuania. People prefer a warmer housing and show interest in recent decisions of engineering systems.
Jevgenija Rutė
doaj +1 more source
QR-CLIP: Introducing Explicit Open-World Knowledge for Location and Time Reasoning [PDF]
, 2023 Weimin Shi +5 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
How does explicit knowledge inform policy shaping? The case of Burkina Faso's national social protection policy. [PDF]
PLoS One, 2023 Kadio K, Dagenais C, Ridde V.
europepmc +1 more source