Results 261 to 270 of about 485,045 (318)

Brain‐Wide Neuroregenerative Gene Therapy Improves Cognition in a Mouse Model of Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
NeuroD1 mediates brain‐wide astrocyte‐to‐neuron gene therapy conversion in 5xFAD mouse brain. Regenerated neurons can fire action potentials and integrate into pre‐existing neural networks, ultimately improving cognition in AD mice. Abstract Alzheimer's disease (AD) is a progressive and irreversible brain disorder with extensive neuronal loss in the ...
Zheng Wu   +10 more
wiley   +1 more source

Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers

open access: yesAdvanced Science, EarlyView.
This study demonstrates that the resveratrol analogue, trans‐4,4′‐dihydroxystilbene (DHS), exhibits synergistic anti‐tumor activity with the PARP inhibitor talazoparib, inducing significant ovarian cancer cell death. The synergistic effect of this combination arises from the concurrent downregulation of homologous recombination factors and the ...
Ganesh Pai Bellare   +7 more
wiley   +1 more source

Impact of correlations on nuclear binding energies: Ab initio calculations of singly and doubly open-shell nuclei. [PDF]

open access: yesEur Phys J A Hadron Nucl
Scalesi A   +5 more
europepmc   +1 more source

Structural Diversity of Mitochondria in the Neuromuscular System across Development Revealed by 3D Electron Microscopy

open access: yesAdvanced Science, EarlyView.
Mitochondria across the entire neuromuscular system have been comprehensively reconstructed at different developmental stages using 3D electron microscopy. Fundamental structural principles related to synaptic function are preserved across development, and these morphologies are adapted to ensure effective neural circuit function.
J. Alexander Bae   +9 more
wiley   +1 more source

Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives

open access: yesAdvanced Science, EarlyView.
This review explores the challenges of treating bone and cartilage defects, emphasizing the role of endogenous electric fields in bone and cartilage regeneration. It highlights recent advancements in electroactive biomaterials, including nanogenerators, piezoelectric materials, triboelectric scaffold, and zwitterionic hydrogels.
Yubin Yao   +4 more
wiley   +1 more source

Small field chaos in spin glasses: Universal predictions from the ultrametric tree and comparison with numerical simulations. [PDF]

open access: yesProc Natl Acad Sci U S A
Aguilar-Janita M   +6 more
europepmc   +1 more source

Progress and Perspectives in 2D Piezoelectric Materials for Piezotronics and Piezo‐Phototronics

open access: yesAdvanced Science, EarlyView.
This review examines advancements in 2D materials, focusing on their applications in piezotronics and piezo‐phototronics. It discusses key materials like TMDs, h‐BN, and phosphorene, highlighting their unique mechanical, electronic, and optical properties.
Fengyi Pang   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy