Results 131 to 140 of about 2,621,041 (313)

Nuclear Electric Propulsion Technology Panel findings and recommendations [PDF]

Summarized are the findings and recommendations of a triagency (NASA/DOE/DOD) panel on Nuclear Electric Propulsion (NEP) Technology. NEP has been identified as a candidate nuclear propulsion technology for exploration of the Moon and Mars as part of the ...
Doherty, Michael P.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Elemental logging evidence for paleoenvironmental reconstruction of the ordovician strata in the Western Ordos basin, China

Scientific Reports
The Ordovician carbonate succession in the western Ordos Basin, China, represents an important target for unconventional hydrocarbon exploration, particularly shale gas in the Wulalike Formation.
Zhenyu Zhao, Xia Zhao, Wei Song, Yueqiao Zhang, Jianrong Gao, Yuanshi Sun, Zhaobing Chen   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Commercial Applications Multispectral Sensor System [PDF]

, 1993
NASA's Office of Commercial Programs is funding a multispectral sensor system to be used in the development of remote sensing applications. The Airborne Terrestrial Applications Sensor (ATLAS) is designed to provide versatility in acquiring spectral and ...
Birk, Ronald J., Spiering, Bruce
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Relative permeability estimation using mercury injection capillary pressure measurements based on deep learning approaches

Journal of Petroleum Exploration and Production Technology
Relative permeability (RP) curves which provide fundamental insights into porous media flow behavior serve as critical parameters in reservoir engineering and numerical simulation studies.
Ce Duan, Bo Kang, Rui Deng, Liang Zhang, Lian Wang, Bing Xu, Xing Zhao, Jianhua Qu   +7 more
doaj   +1 more source

Differential controlling on the deep tight sandstone reservoirs: Insight from the second member of lower Triassic Xujiahe Formation in Xinchang area, western Sichuan basin, China

Journal of Natural Gas Geoscience
With advancements in deep exploration, the deep tight sandstone gas reservoir has become a significant exploration field. However, it remains challenging to develop on a large scale due to the unclear distribution of relatively high-quality reservoirs ...
Pengwei Li, Zongquan Hu, Zhongqun Liu, Shilin Xu, Zhenfeng Liu, Ai Wang, Junlong Liu, Wujun Jin, Yanqing Huang   +8 more
doaj   +1 more source