Results 61 to 70 of about 71,949 (309)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Increasing energy and resource efficiency through innovation: an explorative analysis using innovation survey data [PDF]

Energy and resource efficiency innovations (EREIs) are often seen as win-win opportunities for both the economic and the environmental performance of firms.
Rammer, Christian, Rennings, Klaus
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Green ambidextrous innovation and sustainable performance in Vietnam’s low-carbon transition: The role of green intellectual capital, green ambidextrous leadership, and green entrepreneurial orientation

Journal of Open Innovation: Technology, Market and Complexity
This study examines factors influencing sustainable performance as enterprises implement green innovation in the transition to a low-carbon economy. Drawing on the natural resource-based view (NRBV), the dynamic capability view (DCV), and the triple ...
Ha Nguyen-Van, Anh Hai Le, Chuyen Van Nguyen, Lam Duc Ho, Quynh Thi Thu Nguyen   +4 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Dynamic capabilities and innovation capabilities: The case of the ‘Innovation Clinic’

Journal of Entrepreneurship, Management and Innovation, 2017
In this explorative study, we investigate the relationship between dynamic capabilities and innovation capabilities. Dynamic capabilities are at the core of strategic management in terms of how firms can ensure adaptation to changing environments over ...
Fred Strønen, Thomas Hoholm, Kari Kværner, Linn Nathalie Støme   +3 more
doaj   +1 more source

Ambidextrous Organizational and Individual Competencies in Open Innovation: The Dawn of a new Research Agenda

Journal of Innovation Management, 2014
This paper describes a conceptual approach to individual and organizational competencies needed for Open Innovation (OI) using a new ambidexterity model. It starts from the assumption that the entire innovation process is rarely open by all means, as the
Joachim Hafkesbrink, Markus Schroll
doaj   +1 more source

Tipping the scales: ambidexterity practices on e-HRM projects [PDF]

, 2014
Purpose: We examine and conceptualise the ways in which a balance can be achieved between optimising the efficiency and effectiveness of electronic HRM (e-HRM) systems for human resource management (HRM) and enabling innovation to occur during the system
Carole Tansley, Dr Emma Parry and Professor Stefan Strohmeier, Harry Barton, Hazel Williams, Susan Kirk   +4 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Blockchain Enablers for Supply Chains: How to Boost Implementation in Industry

IEEE Access, 2020
Supply chain management is considered one of the main sectors of development for blockchain technology. This study provides solid contributions to understanding blockchain innovation and presents some main features and guidelines for how to boost ...
Fabio Della Valle, Miquel Oliver
doaj   +1 more source