Results 71 to 80 of about 25,538,498 (274)

What Influences Tourist’ Visit Decision to Coastal Area? A Lesson Learned from Southern Beaches of West Java

Asian Journal of Technology Management, 2020
. Indonesia, as an archipelago country, posits the third rank of the world’s longest coastline list. The potential of coastal tourism was voluminous to be developed in the future. Since the tourism contribution has a positive inclination during the years
Kyoichi Kijima, Santi Novani, Retno Widiana, Yonathan Palumian, Cici Cintyawati   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A Confirmatory Factor Analysis of the Dementia Attitude Scale (DAS) in a European Case Series of Caregivers of People with Dementia Enrolled in the RECage Study

NeuroSci
Background: The Dementia Attitude Scale (DAS) is a validated instrument used to capture the affective, behavioural, and cognitive components of attitudes toward people living with dementia (PLwD).
Bruno Mario Cesana, Eleni Poptsi, Magda Tsolaki, Sverre Bergh, Andrea Fabbo, Lutz Frölich, Maria Cristina Jori, Carlo Alberto Defanti   +7 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Multidimensional symptom clusters: an exploratory factor analysis in advanced chronic kidney disease [PDF]

, 2016
Aims: To explore the existence of symptom clusters in advanced chronic kidney disease. Background: People with chronic kidney disease commonly report multiple symptoms.
Bonner, Ann, Almutary, H, Douglas, C, Bonner, A, Almutary, Hayfa, Douglas, Clint   +5 more
core   +1 more source

EXPLORATORY AND CONFIRMATORY FACTOR ANALYSIS OF A SHORT-FORM OF THE EMBU AMONG CHINESE ADOLESCENTS

, 2012
The present study used a sample of Chinese adolescents and validated a short-form of the Egna Minnen Betraffande Uppfostran: One's Memories of Upbringing (s-EMBU) assessing perceived parental rearing styles.
Zhang, Lisong, Wang, Li, Li, ZQ (reprint author), Nanjing Univ, Dept Psychol, Sch Social & Behav Sci, 22 Hankou Rd, Nanjing 210093, Jiangsu, Peoples R China., Li, Zhongquan   +3 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source