Results 101 to 110 of about 490,079 (300)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Innovation as a community-spanning process: strategies to handle path dependency. [PDF]
In this paper, we further develop and apply the notions of path creation and path dependency during technological innovation processes. The process of technological innovation is portrayed as an activity of spanning boundaries between and across ...
Bouwen, René +2 more
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The impact of Digital Platforms on Business Models: an empirical investigation on innovative start-ups [PDF]
, 2018 Digital platforms have the ability to connect people, organizations and resources with the aim of facilitating the core interactions between businesses and consumers as well as assuring a greater efficiency for the business management.
Bala, Dorina +4 more
core +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Humanities & Social Sciences CommunicationsThis study examines the impact of executives’ postgraduate education on the ambidextrous innovation capabilities of Chinese listed companies, with an emphasis on both exploratory and exploitative innovation.
Pei Chen +3 more
doaj +1 more source
International Review of Economics & FinanceBased on patent application data from A-share listed companies on the Shanghai and Shenzhen stock exchanges in China between 2013 and 2022, this study examines the differential impact and mechanisms of enterprise digital transformation on ambidextrous ...
Ting Li, Shengxu Xiong
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Innovation Networks in the Learning Economy [PDF]
This paper presents breakthroughs of the proposal for a methodology to develop innovation networks with virtual links. It considers stages of analysis, design, implementation and follow up and can be applied to both large companies and SMEs.
Mercy Escalante-Ludena
core
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source