Results 91 to 100 of about 2,505,841 (292)

Open Innovation and Corporate Innovation Hubs: exploratory analysis

open access: yesPhDays 2025 Conference Proceedings
The study investigates the emergence and characteristics of Corporate Innovation Hubs (CIHs) in Italy. Despite their growing prevalence and importance in driving innovation, significant gaps remain in the literature regarding their distinctive features, operational dynamics, and impacts.
openaire   +2 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

The evolution of the ambidextrous innovation synergy strategy of new entrants from the perspective of key core technology monopoly

open access: yesHeliyon
Ambidextrous innovation synergy is an effective way for new entrants and R&D entities to break the blockade of key core technologies. This paper constructs a tripartite evolutionary game model of new entrants, the R&D entity, and monopoly enterprises ...
Shuang Yao, Leke Wu, Donghua Yu
doaj   +1 more source

National Biofilms Innovation Centre Annual Report 2025

open access: yes, 2001
The National Biofilms Innovation Centre (NBIC) Annual Report 2025 covers key achievements to date and future ...
National Biofilms Innovation Centre,
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

How institutional logics hamper innovation: The case of animal testing [PDF]

open access: yes, 2017
For radical innovation to become successful the substitution of established practices are essential. Nevertheless, in the innovation literature novelty is often at the center and only little attention is paid to the influence of established technologies ...
Hekkert, M.P.   +9 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

open access: yesFEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu   +5 more
wiley   +1 more source

Executives’ postgraduate education and corporate ambidextrous innovation: evidence from China’s listed companies

open access: yesHumanities & Social Sciences Communications
This study examines the impact of executives’ postgraduate education on the ambidextrous innovation capabilities of Chinese listed companies, with an emphasis on both exploratory and exploitative innovation.
Pei Chen   +3 more
doaj   +1 more source

The differential impact of enterprise digital transformation on ambidextrous innovation: Evidence from China

open access: yesInternational Review of Economics & Finance
Based on patent application data from A-share listed companies on the Shanghai and Shenzhen stock exchanges in China between 2013 and 2022, this study examines the differential impact and mechanisms of enterprise digital transformation on ambidextrous ...
Ting Li, Shengxu Xiong
doaj   +1 more source

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