Results 71 to 80 of about 2,505,841 (292)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
SystemsIntelligent transformation plays an important role in enhancing innovation capabilities. This study utilizes data from 5000 A-share firms in China to investigate the effects of intelligent transformation on innovation capability and to elucidate the ...
Jingwen Lv, Lu Feng, Wei Xiao, Wei He
doaj +1 more source
Innovating in Journalism with Newsgames: An Exploratory Study in Portugal
Journalism strives to keep up with the new paradigm shift that characterizes Industry 4.0. It finds in innovation possibilities to respond to the various and constant digital changes that impact journalistic practices and to find new business models. Journalistic innovation is mostly associated with the development of apps and new formats for content ...
Frutuoso Costa, Bruno +1 more
openaire +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Investigating co-innovation in exploratory partnerships: An analytical framework based on design theory [PDF]
Intensive innovation contexts push organizations to search for new partnerships in order to explore value creation opportunities and to access external resources.
Akın Kazakçı +2 more
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Exit Statement : 2001-2009 CRC for Construction Innovation [PDF]
, 2009 The Cooperative Research Centre (CRC) for Construction Innovation is Australia’s national centre for research and innovation focused on the needs of the property, design, construction and facility management sectors. The period covered by this report is
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Knowledge management driven leadership, culture and innovation success – an integrative model [PDF]
, 2015 Purpose - This article examines the relation between knowledge management (KM) driven leadership, culture and innovation success of knowledge-intensive small and medium sized companies.
Zięba, M +3 more
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Harnessing capabilities and practices for sourcing innovation: an exploratory study
, 2017 Sourcing innovation has become prevalent only in the recent years; therefore, researchers address the practice of sourcing innovation using various terminologies and there is no fixed definition in the extant literature for sourcing innovation.
Christopher Rajkumar
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source