Results 61 to 70 of about 2,505,841 (292)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

ORGANIZATIONAL AMBIDEXTERITY AND COMPETITIVE ADVANTAGE: TOWARD A RESEARCH MODEL [PDF]

Management & Marketing, 2014
Ambidextrous organizations have the ability to compete in mature markets and to develop new products and services for emerging markets simultaneously.
Gheorghe PREDA
doaj  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Ambidextrous Leadership as an Antecedent of Ambidextrous Innovation

SEISENSE Business Review
The study explores the nexus between ambidextrous leadership and ambidextrous innovation (exploratory and exploitative innovation). The mediating role of psychological safety and job autonomy was assessed based on the leader-member exchange (LMX) and ...
Prince Addai
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Research on the Impact and Path of Human-Machine Collaborative Decision-Making on Dualistic Innovations

IEEE Access
Intelligent and virtualized transformation of the enterprise requires employees to undertake both technological breakthroughs and in-depth development, two innovative activities that seem to compete for resources. How employees, guided by algorithmically
Bin Miao, Jiage Zhang, Jiaxing Zhang, Lu Li, Yitong Hou   +4 more
doaj   +1 more source

Managing exploratory innovation [PDF]

Although the concept of exploration has been widely used in management research since James March's seminal article, the literature on exploration remains rather fuzzy.
Franck Aggeri, Valérie Chanal, Florence Charue-Duboc, Gilles Garel   +3 more
core  

Measurement of innovation capability in supply chain : an exploratory study

, 2016
Purpose: The purpose of this paper is to explore the development of innovation capability construct measures in the context of supply chain and to objectively identify the key dimensions for stimulating focal firms' innovativeness.Design/methodology ...
Iddris, Faisal,
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Innovation, skills and performance in the downturn: an analysis of the UK innovation survey 2011 [PDF]

, 2014
The link between firms’ innovation performance and economic cycles, especially major downturns such as that of 2008-10, is a matter of great policy significance, but is relatively under-researched at least at the level of micro data on business ...
Frenz, Marion, Lambert, Ray
core   +1 more source