Results 51 to 60 of about 2,505,841 (292)

Keeping sustainable innovation on a leash? Exploring incumbents’ institutional strategies [PDF]

, 2015
This research aims to identify the institutional strategies of incumbent firms with regard to sustainable energy innovations that threaten their interests.
Hekkert, M.P., Negro, S.O., Smink, M.M., Innovation Studies, Dynamics of Innovation Systems   +4 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Fueling exploitative and exploratory innovation with paternalistic leadership – do intrinsic motivation and environmental dynamism moderate the relationship? [PDF]

Management Science Letters
The objectives of the study were to investigate 1) whether paternalistic leadership affects exploitative and exploratory innovation, and 2) whether intrinsic motivation and environmental dynamism moderate the direct effects of paternalistic ...
vedha De Costa, Vathsala Wickramasinghe
doaj   +1 more source

Demand, challenges, and innovation. Making sense of new trends in innovation policy [PDF]

, 2018
In recent years, the traditional rationale for innovation policy has been expanded to tackling societal challenges. There is also an increasing agreement that demand should be at the core of this challenge-oriented innovation policy, as for innovations ...
Jakob Edler, Innovation and Sustainability, Wouter Boon, Edler, Jakob; id_orcid, Innovation Studies, Boon, Wouter, Edler, Jakob   +6 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Research on dual innovation incentive mechanism in terms of organizations' differential knowledge absorptive capacity.

PLoS ONE, 2021
Differences in the capacity for absorption between different organizations will have an important impact on an organization's choices of innovation exploration and exploitive innovation strategies.
Xuejiao An, Lin Qi, Jian Zhang, Xinran Jiang   +3 more
doaj   +1 more source

Innovation in Retrospect: An Exploratory Study of Trends in the Levels of Innovation

International Journal of Business and Management, 2015
The 20th century was characterized by growing trends of consumption and the introduction of new products that offered consumers various levels of innovation. The abundance of new products made technological innovation a central characteristic of 20th century consumer culture.
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source