Results 81 to 90 of about 2,505,841 (292)

How AI usage shapes employees’ exploitative and exploratory innovation: joy as a mediator and learning goal orientation as a moderator

open access: yesFrontiers in Human Dynamics
IntroductionEmployees play a pivotal role in organizational ambidextrous innovation, yet existing studies have paid limited attention to how artificial intelligence shapes employees’ exploitative and exploratory innovation. Drawing on cognitive appraisal
Li Liu, Ya Lv
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Perceived value of microfinance and SME performance: The role of exploratory innovation

open access: yesInternational Journal of Innovation Studies
This study examines how perceived value of microfinance and exploratory innovation affect small and medium-sized enterprises (SME) performance in the context of a developing nation.
Christian Sarfo   +3 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Navigating digital transformation challenges: The role of utilization and exploratory innovation in chinese logistics SMEs [PDF]

open access: yesDecision Science Letters
This study investigates the high-quality development of Chinese logistics SMEs by analyzing the effects of digital technology adoption, organizational resilience, utilization innovation, and exploratory innovation.
Fuyuan Yang, Boonsub Panichakarn   +1 more
doaj   +1 more source

Firms’ innovation across regions : an exploratory study [PDF]

open access: yes, 2013
This paper investigates the geographical distribution and concentration of firms’ innovation persistence and innovation type - product and process - based upon three waves of the Community Innovation Survey data covering the period 1998-2006. The main findings are: (i) both innovation persistence and innovation type are asymmetrically distributed ...
Ana Paula Faria   +2 more
openaire   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Cell culture conditions affect the ability of high content imaging assay to detect drug-induced changes in cellular parameters in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)

open access: yesToxicology Reports, 2019
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are widely used for drug safety and efficacy testing with various techniques, including high content imaging (HCI).
Bharathi Balasubramanian   +5 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

Exploring the dual effect of trust in GAI on employees’ exploitative and exploratory innovation

open access: yesHumanities & Social Sciences Communications
The deployment of generative artificial intelligence (GAI) has attracted substantial research attention, yet its impact on employee innovation remains debated.
Xiaoyue Lin, Tiandong Wang, Fan Sheng
doaj   +1 more source

Home - About - Disclaimer - Privacy