Results 11 to 20 of about 575,492 (120)

Mental Condition Monitoring Based on Multimodality Biometry

Frontiers in Public Health, 2020
We have developed a system with multimodality that monitors objective biomarkers for screening the mental distress in the office. A field study using a prototype of the system was performed over four months with 39 volunteers.
Masashi Kiguchi, Stephanie Sutoko, Hirokazu Atsumori, Ayako Nishimura, Akiko Obata, Tsukasa Funane, Hiromitsu Nakagawa, Masashi Egi, Hiroyuki Kuriyama   +8 more
doaj   +1 more source

Very early life microbiome and metabolome correlates with primary vaccination variability in children

mSystems, 2023
Despite multiple vaccine doses early in life, a substantial proportion of infants do not mount protective responses. In this study, we followed a cohort of children over the first 2 years of life, collecting microbiome and metabolome data longitudinally ...
Michael Shaffer, Katharine Best, Catherine Tang, Xue Liang, Steven Schulz, Eduardo Gonzalez, Cory H. White, Thomas P. Wyche, John Kang, Hendrik Wesseling, Begüm D. Topçuoğlu, Thomas Cairns, Theodore R. Sana, Robin M. Kaufhold, Julia M. Maritz, Christopher H. Woelk, Gokul Swaminathan, James E. Norton, Michael E. Pichichero   +18 more
doaj   +1 more source

Using machine learning on clinical data to identify unexpected patterns in groups of COVID-19 patients

Scientific Reports, 2023
As clinicians are faced with a deluge of clinical data, data science can play an important role in highlighting key features driving patient outcomes, aiding in the development of new clinical hypotheses.
Hannah Paris Cowley, Michael S. Robinette, Jordan K. Matelsky, Daniel Xenes, Aparajita Kashyap, Nabeela F. Ibrahim, Matthew L. Robinson, Scott Zeger, Brian T. Garibaldi, William Gray-Roncal   +9 more
doaj   +1 more source

CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade

Nature Communications, 2023
Serine/threonine kinase, cell division cycle 7 (CDC7) is critical for initiating DNA replication. TAK-931 is a specific CDC7 inhibitor, which is a next-generation replication stress (RS) inducer.
Tomoko Yamamori Morita, Jie Yu, Yukie Kashima, Ryo Kamata, Gaku Yamamoto, Tatsunori Minamide, Chiaki Mashima, Miyuki Yoshiya, Yuta Sakae, Toyohiro Yamauchi, Yumi Hakozaki, Shun-ichiro Kageyama, Akito Nakamura, Eric Lightcap, Kosuke Tanaka, Huifeng Niu, Karuppiah Kannan, Akihiro Ohashi   +17 more
doaj   +1 more source

Controlled shape-morphing metallic components for deployable structures

Materials & Design, 2021
Transformational advances in additive manufacturing combined with the unique functional behavior of shape memory alloys (SMAs) has propelled the field of 4D printing “smart” materials. In this study, we leverage multiple processing pathways with additive
Ian D. McCue, Gianna M. Valentino, Douglas B. Trigg, Andrew M. Lennon, Chuck E. Hebert, Drew P. Seker, Salahudin M. Nimer, James P. Mastandrea, Morgana M. Trexler, Steven M. Storck   +9 more
doaj   +1 more source

Isolation and characterization of diverse microbial representatives from the human skin microbiome

Microbiome, 2020
Background The skin micro-environment varies across the body, but all sites are host to microorganisms that can impact skin health. Some of these organisms are true commensals which colonize a unique niche on the skin, while open exposure of the skin to ...
Collin M. Timm, Kristin Loomis, William Stone, Thomas Mehoke, Bryan Brensinger, Matthew Pellicore, Phillip P.A. Staniczenko, Curtisha Charles, Seema Nayak, David K. Karig   +9 more
doaj   +1 more source

The importance of adopting corporate social responsibility to protect the environment in Morocco: Exploratory research [PDF]

E3S Web of Conferences, 2023
Climatic hazards are becoming increasingly worrying in Morocco and elsewhere, leading to serious socio-economic and especially environmental effects, such as the drought that has become severe in Morocco, water stress, and climate change.
Arrafiki Imane, Barmaki Loubna
doaj   +1 more source

Vaccine Hyporesponse Induced by Individual Antibiotic Treatment in Mice and Non-Human Primates Is Diminished upon Recovery of the Gut Microbiome

Vaccines, 2021
Emerging evidence demonstrates a connection between microbiome composition and suboptimal response to vaccines (vaccine hyporesponse). Harnessing the interaction between microbes and the immune system could provide novel therapeutic strategies for ...
Gokul Swaminathan, Michael Citron, Jianying Xiao, James E. Norton, Abigail L. Reens, Begüm D. Topçuoğlu, Julia M. Maritz, Keun-Joong Lee, Daniel C. Freed, Teresa M. Weber, Cory H. White, Mahika Kadam, Erin Spofford, Erin Bryant-Hall, Gino Salituro, Sushma Kommineni, Xue Liang, Olga Danilchanka, Jane A. Fontenot, Christopher H. Woelk, Dario A. Gutierrez, Daria J. Hazuda, Geoffrey D. Hannigan   +22 more
doaj   +1 more source

Desiccation-induced fibrous condensation of CAHS protein from an anhydrobiotic tardigrade

Scientific Reports, 2021
Anhydrobiosis, one of the most extensively studied forms of cryptobiosis, is induced in certain organisms as a response to desiccation. Anhydrobiotic species has been hypothesized to produce substances that can protect their biological components and/or ...
Maho Yagi-Utsumi, Kazuhiro Aoki, Hiroki Watanabe, Chihong Song, Seiji Nishimura, Tadashi Satoh, Saeko Yanaka, Christian Ganser, Sae Tanaka, Vincent Schnapka, Ean Wai Goh, Yuji Furutani, Kazuyoshi Murata, Takayuki Uchihashi, Kazuharu Arakawa, Koichi Kato   +15 more
doaj   +1 more source

Identification of CD73 as the Antigen of an Antigen-Unknown Monoclonal Antibody Established by Exosome Immunization, and Its Antibody–Drug Conjugate Exerts an Antitumor Effect on Glioblastoma Cell Lines

Pharmaceuticals, 2022
Development of antibodies against the native structure of membrane proteins with multiple transmembrane domains is challenging because it is difficult to prepare antigens with native structures. Previously, we successfully developed a monoclonal antibody
Takahiro Anzai, Shinji Saijou, Hiroki Takashima, Misato Hara, Shingo Hanaoka, Yasuhiro Matsumura, Masahiro Yasunaga   +6 more
doaj   +1 more source