Results 31 to 40 of about 575,492 (120)

Combination treatment with a PI3K/Akt/mTOR pathway inhibitor overcomes resistance to anti-HER2 therapy in PIK3CA-mutant HER2-positive breast cancer cells

Scientific Reports, 2020
Amplification and/or overexpression of human epidermal growth factor receptor 2 (HER2) are observed in 15–20% of breast cancers (HER2+ breast cancers), and anti-HER2 therapies have significantly improved prognosis of patients with HER2+ breast cancer ...
Yumi Fujimoto, Tomoko Yamamori Morita, Akihiro Ohashi, Hiroshi Haeno, Yumi Hakozaki, Masanori Fujii, Yukie Kashima, Susumu S. Kobayashi, Toru Mukohara   +8 more
doaj   +1 more source

Long descending commissural V0v neurons ensure coordinated swimming movements along the body axis in larval zebrafish

Scientific Reports, 2022
Developmental maturation occurs in slow swimming behavior in larval zebrafish; older larvae acquire the ability to perform slow swimming while keeping their head stable in the yaw dimension.
Kohei Kawano, Kagayaki Kato, Takumi Sugioka, Yukiko Kimura, Masashi Tanimoto, Shin-ichi Higashijima   +5 more
doaj   +1 more source

Décrire et comprendre l’apprentissage dans les dispositifs hybrides de formation

Distances et Médiations des Savoirs, 2021
Students entering higher education today are faced with a variety of hybrid and online learning environments. This research, conducted prior to the COVID-19 pandemic, aims to address gaps in knowledge about the interactions between students ...
Bernadette Charlier, Claire Peltier, Maria Ruberto   +2 more
doaj   +1 more source

Telehealth nursing interventions for phenotypes of older adults with COPD: an exploratory study

Frontiers in Digital Health, 2023
IntroductionInconclusive results exist around the effectiveness of telemonitoring for patients with COPD, and studies recommended conducting subgroup analyses to identify patient phenotypes that could benefit from these services.
A. Arnaert, A.M.I. Ahmed, Z. Debe, S. Charbonneau, S. Paul   +4 more
doaj   +1 more source

Deciphering the sub-Golgi localization of glycosyltransferases via 3D super-resolution imaging

Cell Structure and Function
The Golgi apparatus, a crucial organelle involved in protein processing, including glycosylation, exhibits complex sub-structures, i.e., cis-, medial, and trans-cisternae.
Hirokazu Yagi, Seigo Tateo, Taiki Saito, Yusaku Ohta, Emiko Nishi, Saemi Obitsu, Tatsuya Suzuki, Supaphorn Seetaha, Charles Hellec, Akihiko Nakano, Takuro Tojima, Koichi Kato   +11 more
doaj   +1 more source

BayesianSSA: a Bayesian statistical model based on structural sensitivity analysis for predicting responses to enzyme perturbations in metabolic networks

BMC Bioinformatics
Background Chemical bioproduction has attracted attention as a key technology in a decarbonized society. In computational design for chemical bioproduction, it is necessary to predict changes in metabolic fluxes when up-/down-regulating enzymatic ...
Shion Hosoda, Hisashi Iwata, Takuya Miura, Maiko Tanabe, Takashi Okada, Atsushi Mochizuki, Miwa Sato   +6 more
doaj   +1 more source

Experiences of antibiotic use among Brazilian healthcare users: An exploratory study

Health Expectations, 2023
Introduction This article analyzes experiences of antibiotic use and bacterial infections among Primary Health Care users of the Brazilian Unified Health System (SUS) and the possible implications for antimicrobial resistance (AMR).
Luiz F. Zago, Juliana S. Correa, Roberto R. daSilva‐Brandão, Lislaine A. Fracolli, Maria Clara Padoveze, Sandi Michele deOliveira, Gloria C. Corboda Currea   +6 more
doaj   +1 more source

PARP inhibitors elicit a cellular senescence mediated inflammatory response in homologous recombination proficient cancer cells

Scientific Reports
Poly (ADP-ribose) polymerase (PARP) inhibitors have improved the prognosis of homologous recombination deficient (HRD) ovarian cancer (OC), while effective therapeutic strategies for HR-proficient (HRP) OC still need to be established.
Misato Kamii, Ryo Kamata, Hitoshi Saito, Gaku Yamamoto, Chiaki Mashima, Toyohiro Yamauchi, Takehiro Nakao, Yuta Sakae, Tomoko Yamamori-Morita, Kazuki Nakai, Yumi Hakozaki, Masataka Takenaka, Aikou Okamoto, Akihiro Ohashi   +13 more
doaj   +1 more source

Phase I study of glypican-3-derived peptide vaccine therapy for patients with refractory pediatric solid tumors

OncoImmunology, 2018
The carcinoembryonic antigen glypican-3 (GPC3) is a good target of anticancer immunotherapy against pediatric solid tumors expressing GPC3. In this non-randomized, open-label, phase I clinical trial, we analyzed the safety and efficacy of GPC3-peptide ...
Nobuhiro Tsuchiya, Ako Hosono, Toshiaki Yoshikawa, Kayoko Shoda, Kazuto Nosaka, Manami Shimomura, Junichi Hara, Chika Nitani, Atsushi Manabe, Hiroki Yoshihara, Yosuke Hosoya, Hide Kaneda, Yoshiaki Kinoshita, Kenichi Kohashi, Kenichi Yoshimura, Norihiro Fujinami, Keigo Saito, Shoichi Mizuno, Tetsuya Nakatsura   +18 more
doaj   +1 more source

Soluble Frizzled-related proteins promote exosome-mediated Wnt re-secretion

Communications Biology
Wnt proteins are thought to be transported in several ways in the extracellular space. For instance, they are known to be carried by exosomes and by Wnt-carrier proteins, such as sFRP proteins.
Thi Hong Nguyen Tran, Ritsuko Takada, Elena Krayukhina, Takahiro Maruno, Yusuke Mii, Susumu Uchiyama, Shinji Takada   +6 more
doaj   +1 more source