Results 21 to 30 of about 575,492 (120)

Pharmacologic consequences of cholesterol absorption inhibition: alteration in cholesterol metabolism and reduction in plasma cholesterol concentration induced by the synthetic saponin beta-tigogenin cellobioside (CP-88818; tiqueside).

Journal of Lipid Research, 1993
Natural and synthetic saponins inhibit cholesterol absorption and reduce plasma cholesterol levels in experimental animals and are therefore of potential pharmacologic utility in the treatment of hypercholesterolemia.
HJ Harwood, Jr, CE Chandler, LD Pellarin, FW Bangerter, RW Wilkins, CA Long, PG Cosgrove, MR Malinow, CA Marzetta, JL Pettini   +9 more
doaj   +1 more source

Connectomics Annotation Metadata Standardization for Increased Accessibility and Queryability

Frontiers in Neuroinformatics, 2022
Neuroscientists can leverage technological advances to image neural tissue across a range of different scales, potentially forming the basis for the next generation of brain atlases and circuit reconstructions at submicron resolution, using Electron ...
Morgan Sanchez, Dymon Moore, Erik C. Johnson, Brock Wester, Jeff W. Lichtman, William Gray-Roncal   +5 more
doaj   +1 more source

Novel stromal biomarker screening in pancreatic cancer patients using the in vitro cancer-stromal interaction model

BMC Gastroenterology, 2020
Background Stromal fibroblasts associated with pancreatic ductal adenocarcinoma (PDAC) play an important role in tumor progression through interactions with cancer cells.
Yasunori Nishida, Akiko Kawano Nagatsuma, Motohiro Kojima, Naoto Gotohda, Atsushi Ochiai   +4 more
doaj   +1 more source

Response Style Characterization for Repeated Measures Using the Visual Analogue Scale

IEEE Access
Self-report measures (e.g., Likert scales) are widely used to evaluate subjective health perceptions. Recently, the visual analog scale (VAS), a slider-based scale, has become popular owing to its ability to precisely and easily assess how people feel ...
Shunsuke Minusa, Tadayuki Matsumura, Kanako Esaki, Yang Shao, Chihiro Yoshimura, Hiroyuki Mizuno   +5 more
doaj   +1 more source

Protection from contamination by 211At, an enigmatic but promising alpha-particle-emitting radionuclide

EJNMMI Physics, 2022
Purpose 211At, a promising alpha-particle-emitting radionuclide, can easily volatilize and contaminate the environment. To safely manage this unique alpha-particle-emitting radionuclide, we investigated the permeability of four types of plastic films and
Kazunobu Ohnuki, Mitsuyoshi Yoshimoto, Hiromitsu Haba, Shino Manabe, Hiroki Takashima, Masahiro Yasunaga, Yasumasa Takenaka, Hirofumi Fujii   +7 more
doaj   +1 more source

Enhancement of antitumor effect by peptide vaccine therapy in combination with anti-CD4 antibody: Study in a murine model

Biochemistry and Biophysics Reports, 2016
Purpose: The clinical efficacy of cancer peptide vaccine therapy is insufficient. To enhance the anti-tumor effect of peptide vaccine therapy, we combined this therapy with an anti-CD4 mAb (GK1.5), which is known to deplete CD4+ cells, including ...
Norihiro Fujinami, Toshiaki Yoshikawa, Yu Sawada, Manami Shimomura, Tatsuaki Iwama, Shiori Sugai, Shigehisa Kitano, Yasushi Uemura, Tetsuya Nakatsura   +8 more
doaj   +1 more source

Crystal growth and flat-band effects on thermoelectric properties of Fe2TiAl-based full-Heusler thin films

AIP Advances, 2020
In this study, various Fe-based thermoelectric full-Heusler thin films were fabricated on MgO substrates by a post-annealing process. It is clarified that crystal growth through the post-annealing process is prevented by both an initial crystallization ...
Y. Kurosaki, S. Yabuuchi, A. Nishide, N. Fukatani, J. Hayakawa   +4 more
doaj   +1 more source

Practical Considerations for Laser-Induced Graphene Pressure Sensors Used in Marine Applications

Sensors, 2023
Small, low-power, and inexpensive marine depth sensors are of interest for a myriad of applications from maritime security to environmental monitoring. Recently, laser-induced graphene (LIG) piezoresistive pressure sensors have been proposed given their ...
Tessa Van Volkenburg, Daniel Ayoub, Andrea Alemán Reyes, Zhiyong Xia, Leslie Hamilton   +4 more
doaj   +1 more source

Immunomodulation by the Commensal Microbiome During Immune-Targeted Interventions: Focus on Cancer Immune Checkpoint Inhibitor Therapy and Vaccination

Frontiers in Immunology, 2021
Emerging evidence in clinical and preclinical studies indicates that success of immunotherapies can be impacted by the state of the microbiome. Understanding the role of the microbiome during immune-targeted interventions could help us understand ...
Abigail L. Reens, Damien J. Cabral, Xue Liang, James E. Norton, Alex G. Therien, Daria J. Hazuda, Daria J. Hazuda, Gokul Swaminathan   +7 more
doaj   +1 more source

Beneficial Role of Carica papaya Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review

Biology, 2021
Oxidative stress is a result of disruption in the balance between antioxidants and pro-oxidants in which subsequently impacting on redox signaling, causing cell and tissue damages.
Yew Rong Kong, Yong Xin Jong, Manisha Balakrishnan, Zhui Ken Bok, Janice Kwan Kah Weng, Kai Ching Tay, Bey Hing Goh, Yong Sze Ong, Kok Gan Chan, Learn Han Lee, Kooi Yeong Khaw   +10 more
doaj   +1 more source