Results 51 to 60 of about 786,670 (261)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Level Sets Guided by SoDEF-Fitting Energy for River Channel Detection in SAR Images
Remote Sensing, 2023 To achieve river channel detection in SAR (synthetic aperture radar) images, we developed a level-set-based model (LSBM) guided by a designed data-fitting energy which is called the SoDEF (sum of dual exponential functions)-fitting energy.
Bin Han, Anup Basu
doaj +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
On a Diophantine equation involving fractional powers with primes of special types
AIMS MathematicsSuppose that $ N $ is a sufficiently large real number. In this paper it is proved that for $ 2 < c < \frac{990}{479} $, the Diophantine equation $ \left[p_{1}^{c}\right]+\left[p_{2}^{c}\right]+\left[p_{3}^{c}\right]+\left[p_{4}^{c}\right ...
Liuying Wu
doaj +1 more source
Low Rank Matrix Completion with Exponential Family Noise [PDF]
, 2015 The matrix completion problem consists in reconstructing a matrix from a sample of entries, possibly observed with noise. A popular class of estimator, known as nuclear norm penalized estimators, are based on minimizing the sum of a data fitting term and
Lafond, Jean
core +1 more source
Monte Carlo Methods for Insurance Risk Computation
, 2018 In this paper we consider the problem of computing tail probabilities of the distribution of a random sum of positive random variables. We assume that the individual variables follow a reproducible natural exponential family (NEF) distribution, and that ...
Bar-Lev, Shaul, Ridder, Ad
core +2 more sources
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
, 2023 Using combinatorial techniques, we derive a recurrence identity that expresses an exponential power sum with negative powers in terms of another exponential power sum with positive powers. Consequently, we derive a formula for the power sum of the first $k$ natural numbers when the power is odd, which when used in combination with Faulhaber's formula ...
Thomas, Neha Elizabeth +1 more
openaire +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
A class of small multiplicative functions in Piatetski-Shapiro sequences
AIMS MathematicsFor any real number $ x, [x] $ denotes the integer part of $ x $. $ \mathcal{F}_{1} $ denotes a class of multiplicative functions that are small in a numerical sense.
Haihong Fan
doaj +1 more source