Results 21 to 30 of about 9,640 (238)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
On Some Dynamical Systems in Finite Fields and Residue Rings
, 2007 We use character sums to confirm several recent conjectures of V. I. Arnold on the uniformity of distribution properties of a certain dynamical system in a finite field. On the other hand, we show that some conjectures are wrong.
Shparlinski, Igor E.
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
EXPONENTIAL SUMS OVER POINTS OF ELLIPTIC CURVES WITH RECIPROCALS OF PRIMES [PDF]
, 2017 We consider exponential sums with x-coordinates of points qG and q−1G where G is a point of order T on an elliptic curve modulo a prime p and q runs through all primes up toN (with gcd (q,T)=1 in the case of the points q−1G).
Ostafe, Alina, Shparlinski, Igor E.
core
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Brun's Fundamental Lemma and Exponential Sums over Primes
Journal of Number Theory, 2001 Using only a fundamental lemma in sieve methods together with Chebyshev's estimate for the average value for the von Mangoldt function \(\Lambda(n)\), the author establishes the bound for the exponential sum \[ \sum_{n\leq x}\Lambda(n)e^{2\pi i\alpha n}\ll x \sqrt{{d(q)\log^3q\over \varphi(q)}}, \] where \(d(q)\) is the divisor function and \(\varphi(q)
openaire +2 more sources
A conditional result on exponential sums over primes in short intervals
, 2022 The poof contained some ...
Bellotti, Chiara, Puglisi, Giuseppe
openaire +2 more sources
Exponential sums with automatic sequences
, 2017 We show that automatic sequences are asymptotically orthogonal to periodic exponentials of type $e_q(f(n))$, where $f$ is a rational fraction, in the P\'olya-Vinogradov range.
Drappeau, Sary, Müllner, Clemens
core +3 more sources