Results 41 to 50 of about 9,690 (225)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
A conditional result on exponential sums over primes in short intervals
, 2022 The poof contained some ...
Bellotti, Chiara, Puglisi, Giuseppe
openaire +2 more sources
Vinogradov's three primes theorem with almost twin primes
, 2017 In this paper we prove two results concerning Vinogradov's three primes theorem with primes that can be called almost twin primes. First, for any $m$, every sufficiently large odd integer $N$ can be written as a sum of three primes $p_1, p_2$ and $p_3 ...
Matomäki, Kaisa, Shao, Xuancheng
core +1 more source
On matrix elements for the quantized cat map modulo prime powers
, 2008 The quantum cat map is a model for a quantum system with underlying chaotic dynamics. In this paper we study the matrix elements of smooth observables in this model, when taking arithmetic symmetries into account. We give explicit formulas for the matrix
Kelmer, Dubi
core +3 more sources
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Pair Correlation of Zeros, Primes in Short Intervals and Exponential Sums over Primes
Journal of Number Theory, 2000 Let \(S(\alpha) = \sum_{n\leq X}\Lambda(n)e(n\alpha)\), where \(e(x)=e^{2\pi ix}\), and \(\Lambda(n)\) is the von Mangoldt function defined to be \(\log p\) if \(n=p^m\), \(p\) a prime, \(m\geq 1\), and zero otherwise. This paper is concerned with the short \(L^2\) mean \[ S(X,\xi) = \int_{-\xi}^\xi |S(\alpha)|^2 d\alpha , \] with \(0\leq \xi \leq {1 ...
A. LANGUASCO, PERELLI, ALBERTO
openaire +3 more sources
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source