Results 211 to 220 of about 22,123 (294)

Aging-declined RNA exportation impairs hematopoietic stem cells by inducing R-loop. [PDF]

Haematologica
Chen R, Dong Q, Zhou L, He H, Du Y, Sun Q, Suda T, Cheng T, Wang J.   +8 more
europepmc   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Micro-computed tomography of termite gut anatomy: effects of staining regime on resolvability. [PDF]

PeerJ
Blamires SJ, Sansom T, Oberst S.
europepmc   +1 more source

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source

New insights in the diagnosis and treatment of equine piroplasmosis: pitfalls, idiosyncrasies, and myths. [PDF]

Front Vet Sci
Mendoza FJ, Pérez-Écija A, Kappmeyer LS, Suarez CE, Bastos RG.   +4 more
europepmc   +1 more source

A State‐Gated Metallo‐DNAzyme Framework Programs Tumor Stress Vulnerability Through Metabolic Licensing

Advanced Science, EarlyView.
A tumor‐state‐gated metallo‐DNAzyme framework integrates miR‐21/APE1‐responsive GLUT1 silencing with Ca/Cu‐partitioned metal–nucleic acid assembly and cystine loading. The framework first weakens glucose‐dependent metabolic buffering and then amplifies copper‐ and disulfide‐associated stress, converting tumor metabolic adaptation into programmable ...
Xiaodong Ma, Lingyun He, Xinru Wang, Yuanyuan Wei, Chengcheng Li, Jiaqi Yan, Weijian Sun, Xian Shen, Hongbo Zhang   +8 more
wiley   +1 more source

Disturbances of endoplasmic reticulum proteostasis in neurodevelopmental disorders. [PDF]

Biochem Soc Trans
Medinas DB, Pereira N, Pereira R, da Silva GR, Santos VHS.   +4 more
europepmc   +1 more source

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

Advanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source

The Evolutionary Dynamics and Regional Spread of Mpox in Africa: Insights from Multi-country Genomic Surveillance

Tanui CK, Lusamaki EK, O’Toole Á, Chitenje M, Campbell AK, Diagne MM, Kanyerezi S, Faye M, Ifabumuyi SO, Nzoyikorera N, Lango HO, Koukouikila-Koussounda F, Meite S, Sikazwe E, Djuicy DD, Adu B, Maman I, Mapunda LA, Nyan DC, Stephane S, Aricha SA, Chérif Gnimadi TA, Maror JA, Pereira AM, Atrah YS, Akanbi OA, Lokilo EL, Paku PT, Makangara-Cigolo J, Luakanda GN, Amuri-Aziza A, Wawina-Bokalanga T, Mugerwa I, Nsawotebba A, Ayitewala A, Williams AJ, Folorunso V, Mani S, Harding D, Avong JC, Chukwu C, Ahmad A, Uwineza MN, Nizigiyimana D, Nduwimana C, Ihorimbere T, Koffi B, Sibiro OA, Malaka CN, Mayengue PI, Elenga RG, Eyenet Boussam DA, Munster VJ, Yinda CK, Yavo AK, Adjogoua EV, Ouattara YK, Sylla A, Mutale J, Kasongo C, Essomba RG, Esso L, Boutgam NL, Godwe C, Mbesse GE, Nyanga S, Claver JP, Getu M, Shobayo BI, Donzo KS, Nyilah SO, Aimé G, Roba A, Akasa S, Ireri S, Ndia MN, Soumah AK, Diallo H, Keita AK, Toure A, Mwanyongo A, Misomali C, Matthew K, Wani Lako JD, Dumo GW, Deng LL, de Morais Afonso JFM, De Vasconcelos N, Faria NR, Mombo IM, Maganga GD, N’dilimabaka N, Grobbelaar A, Featherston J, Kebede A, Inglês Samuel LLM, Othow AA, Bangoh JB, Nyenje M, Keita AK, Sigilai EM, Anges Y, Leta GT, Tollera G, Mwafulango A, Kofi Bonney JH, Kouanfack C, Ayouba A, Weyer J, Hamsatou H, Chilengi R, Kadjo HA, Nakoune E, Sow A, Niama FR, Lango-yaya E, Nyandwi J, Idris J, Babatunde O, Sahr F, Njouom R, Nabadda S, Rambaut A, Ssewanyana I, Kingebeni PM, Tessema SK, Tebeje YK.   +126 more
europepmc   +1 more source

Role of the Labrador Current in the Atlantic Meridional Overturning Circulation response to greenhouse warming. [PDF]

Nat Commun
Shan X, Sun S, Wu L, Spall M.
europepmc   +1 more source