Results 31 to 40 of about 40,637 (278)

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Land Cover Controls the Export of Terminal Electron Acceptors from Boreal Catchments [PDF]

Ecosystems, 2014
NO3, Mn, Fe, and SO4 act as terminal electron acceptors (TEAs), modifying mineralization pathways and coupling biogeochemical cycles. Although single TEA concentrations and fluxes have been intensively studied, the factors regulating the simultaneous fluxes and molar ratios of TEAs are poorly elucidated. We studied the mean concentrations, exports, and
Palviainen, Marjo, Lehtoranta, Jouni, Ekholm, Petri, Ruoho-Airola, Tuija, Kortelainen, Pirkko   +4 more
openaire   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Modules program structures and the structuring of operating systems [PDF]

, 1981
In this paper some views are presented on the way in which complex systems, such as Operating Systems and the programs to be interfaced with them can be constructed, and how such systems may become heavily library oriented.
Bron, C.
core   +3 more sources

N-Terminal Gag Domain Required for Foamy Virus Particle Assembly and Export [PDF]

Journal of Virology, 2005
ABSTRACT Among the Retroviridae , foamy viruses (FVs) exhibit an unusual way of particle assembly and a highly specific incorporation of envelope protein into progeny virions. We have analyzed deletions and point mutants of the prototypic FV gag gene for capsid assembly and egress ...
Marc, Cartellieri, Ottmar, Herchenröder, Wolfram, Rudolph, Martin, Heinkelein, Dirk, Lindemann, Hanswalter, Zentgraf, Axel, Rethwilm   +6 more
openaire   +2 more sources

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

ANTI-DUMPING IN AGRICULTURE BETWEEN CANADA AND THE UNITED STATES: TWO CASES OF TOMATOES [PDF]

, 2010
International Relations/Trade,
Azhough, Ramin, Barband, Ali Reza, Motayagheni, Negar, Niafar, Mitra, Pourfathi, Hojjat   +4 more
core   +2 more sources

The C-terminal portion of the cleaved HT motif is necessary and sufficient to mediate export of proteins from the malaria parasite into its host cell [PDF]

, 2012
The malaria parasite exports proteins across its plasma membrane and a surrounding parasitophorous vacuole membrane, into its host erythrocyte. Most exported proteins contain a Host Targeting motif (HT motif) that targets them for export. In the parasite
Cryar, Adam, Haldar, K., Osborne, Andrew R., Tarr, Sarah J., Thalassinos, Konstantinos   +4 more
core   +1 more source

Born to Be Exported: COOH-Terminal Nuclear Export Signals of Different Strength Ensure Cytoplasmic Accumulation of Nucleophosmin Leukemic Mutants [PDF]

Cancer Research, 2007
Abstract Creation of a nuclear export signal (NES) motif and loss of tryptophans (W) 288 and 290 (or 290 only) at the COOH terminus of nucleophosmin (NPM) are both crucial for NPM aberrant cytoplasmic accumulation in acute myelogenous leukemia (AML) carrying NPM1 mutations.
BOLLI, NICCOLO', NICOLETTI, Ildo, De Marco M. F., Bigerna B., PUCCIARINI, Alessandra, MANNUCCI, Roberta, MARTELLI, Maria Paola, LISO, Arcangelo, MECUCCI, Cristina, Fabbiano F., MARTELLI, Massimo Fabrizio, Henderson B., FALINI, Brunangelo   +12 more
openaire   +4 more sources