Results 11 to 20 of about 40,773 (278)

Proton export upregulates aerobic glycolysis

BMC Biology, 2022
Introduction Aggressive cancers commonly ferment glucose to lactic acid at high rates, even in the presence of oxygen. This is known as aerobic glycolysis, or the “Warburg Effect.” It is widely assumed that this is a consequence of the upregulation of ...
Shonagh Russell, Liping Xu, Yoonseok Kam, Dominique Abrahams, Bryce Ordway, Alex S. Lopez, Marilyn M. Bui, Joseph Johnson, Tamir Epstein, Epifanio Ruiz, Mark C. Lloyd, Pawel Swietach, Daniel Verduzco, Jonathan Wojtkowiak, Robert J. Gillies   +14 more
doaj   +1 more source

Rab5b-Associated Arf1 GTPase Regulates Export of N-Myristoylated Adenylate Kinase 2 From the Endoplasmic Reticulum in Plasmodium falciparum

Frontiers in Cellular and Infection Microbiology, 2021
Plasmodium falciparum extensively remodels human erythrocytes by exporting hundreds of parasite proteins. This remodeling is closely linked to the Plasmodium virulence-related functions and immune evasion.
Izumi Taku, Izumi Taku, Tomohiro Hirai, Tomohiro Hirai, Takashi Makiuchi, Naoaki Shinzawa, Shiroh Iwanaga, Takeshi Annoura, Kisaburo Nagamune, Kisaburo Nagamune, Tomoyoshi Nozaki, Yumiko Saito-Nakano   +11 more
doaj   +1 more source

N-terminal processing of proteins exported by malaria parasites [PDF]

Molecular and Biochemical Parasitology, 2008
Malaria parasites utilize a short N-terminal amino acid motif termed the Plasmodium export element (PEXEL) to export an array of proteins to the host erythrocyte during blood stage infection. Using immunoaffinity chromatography and mass spectrometry, insight into this signal-mediated trafficking mechanism was gained by discovering that the PEXEL motif ...
Henry H, Chang, Arnold M, Falick, Peter M, Carlton, John W, Sedat, Joseph L, DeRisi, Michael A, Marletta   +5 more
openaire   +2 more sources

Problems of developing the customs and logistics infrastructure of the East-West International Transport Corridor

RUDN Journal of Economics, 2020
The aim of this work is to identify key aspects of the impact of customs and logistics infrastructure on patterns of change in trade between the countries participating in the East-West International Transport Corridor.
Roman V. Fedorenko
doaj   +1 more source

YSIRK-G/S-directed translocation is required for Streptococcus suis to deliver diverse cell wall anchoring effectors contributing to bacterial pathogenicity

Virulence, 2020
The Streptococcus suis serotype 2 (SS2) is a significant zoonotic pathogen that is responsible for various swine diseases, even causing cytokine storms of Streptococcal toxic shock-like syndromes amongst human.
Qiankun Bai, Jiale Ma, Ze Zhang, Xiaojun Zhong, Zihao Pan, Yinchu Zhu, Yue Zhang, Zongfu Wu, Guangjin Liu, Huochun Yao   +9 more
doaj   +1 more source

Twin arginine translocation system in secretory expression of recombinant human growth hormone

Research in Pharmaceutical Sciences, 2016
Recombinant protein production in E. coli has several advantages over other expression systems. Misfolding, inclusion body formation, and lack of eukaryotic post translational modification are the most disadvantages of this system. Exporting of correctly
Mohammad Reza Bagherinejad, Hamid Mir-Mohammad Sadeghi, Daryoush Abedi, C Perry Chou, Fatemeh Moazen, Mohammad Rabbani   +5 more
doaj   +1 more source

Dimerization of ABCG2 analysed by bimolecular fluorescence complementation.

PLoS ONE, 2011
ABCG2 is one of three human ATP binding cassette transporters that are functionally capable of exporting a diverse range of substrates from cells. The physiological consequence of ABCG2 multidrug transport activity in leukaemia, and some solid tumours is
Ameena J Haider, Deborah Briggs, Tim J Self, Hannah L Chilvers, Nicholas D Holliday, Ian D Kerr   +5 more
doaj   +1 more source

A novel mutation in isoform 3 of the plasma membrane Ca2+ pump impairs cellular Ca2+ homeostasis in a patient with cerebellar ataxia and laminin subunit 1\u3b1 mutations. [PDF]

, 2015
The particular importance of Ca2+ signaling to neurons demands its precise regulation within their cytoplasm. Isoform 3 of the plasma membrane Ca2+ ATPase (the PMCA3 pump), which is highly expressed in brain and cerebellum, plays an important role in the
Brini, Marisa, Cali', Tito, Carafoli, Ernesto, Frizzarin, Martina, Lopreiato, Raffaele, Shimony, J, Shinawi, M, Vineyard, M, Zanni, G, Zanotti, Giuseppe   +9 more
core   +1 more source

Effects of POD control on a DFIG wind turbine structural system [PDF]

, 2020
This paper investigates the effects power oscillation damping (POD) controller could have on a wind turbine structural system. Most of the published work in this area has been done using relatively simple aerodynamic and structural models of a wind ...
Baloch, Shurooque, Edrah, Mohamed, Hung, William, Karcanias, Aris, Marshall, Benjamin, Qi, Pengyuan, Zhao, Xiaowei   +6 more
core   +1 more source

Engineering the Salmonella type III secretion system to export spider silk monomers

Molecular Systems Biology, 2009
The type III secretion system (T3SS) exports proteins from the cytoplasm, through both the inner and outer membranes, to the external environment. Here, a system is constructed to harness the T3SS encoded within Salmonella Pathogeneity Island 1 to export
Daniel M Widmaier, Danielle Tullman‐Ercek, Ethan A Mirsky, Rena Hill, Sridhar Govindarajan, Jeremy Minshull, Christopher A Voigt   +6 more
doaj   +1 more source