Results 31 to 40 of about 40,773 (278)

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Tax compliance cost and international trade in Africa [PDF]

, 2019
International trade in Africa could be one of the antidotes to the precarious poverty and economic deficiency in which the continent finds itself. An outward orientation towards international trade opens the continent to many opportunities including an ...
Ablorde, Francis, Asorwoe, Elvis, Atiase, Victor, Kolade, Oluwaseun   +3 more
core  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Land Cover Controls the Export of Terminal Electron Acceptors from Boreal Catchments [PDF]

Ecosystems, 2014
NO3, Mn, Fe, and SO4 act as terminal electron acceptors (TEAs), modifying mineralization pathways and coupling biogeochemical cycles. Although single TEA concentrations and fluxes have been intensively studied, the factors regulating the simultaneous fluxes and molar ratios of TEAs are poorly elucidated. We studied the mean concentrations, exports, and
Palviainen, Marjo, Lehtoranta, Jouni, Ekholm, Petri, Ruoho-Airola, Tuija, Kortelainen, Pirkko   +4 more
openaire   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Modules program structures and the structuring of operating systems [PDF]

, 1981
In this paper some views are presented on the way in which complex systems, such as Operating Systems and the programs to be interfaced with them can be constructed, and how such systems may become heavily library oriented.
Bron, C.
core   +3 more sources

N-Terminal Gag Domain Required for Foamy Virus Particle Assembly and Export [PDF]

Journal of Virology, 2005
ABSTRACT Among the Retroviridae , foamy viruses (FVs) exhibit an unusual way of particle assembly and a highly specific incorporation of envelope protein into progeny virions. We have analyzed deletions and point mutants of the prototypic FV gag gene for capsid assembly and egress ...
Marc, Cartellieri, Ottmar, Herchenröder, Wolfram, Rudolph, Martin, Heinkelein, Dirk, Lindemann, Hanswalter, Zentgraf, Axel, Rethwilm   +6 more
openaire   +2 more sources

Light Activated Induction of Cuproptosis in Resistant Cancer Cells Using Polymeric BODIPY Nanoparticles for Photoactivated Chemotherapy

Advanced Functional Materials, EarlyView.
This article presents a photo‐responsive nanoparticle platform that precisely triggers copper‐dependent cuproptotic cell death in (drug‐resistant) cancer cells. The system remains stable and inactive in the dark but releases cytotoxic species upon red‐light irradiation, achieving potent activity in drug‐resistant breast cancer cells.
Ricarda Zimmermann, Nicolás Montesdeoca, Johannes Karges   +2 more
wiley   +1 more source

Born to Be Exported: COOH-Terminal Nuclear Export Signals of Different Strength Ensure Cytoplasmic Accumulation of Nucleophosmin Leukemic Mutants [PDF]

Cancer Research, 2007
Abstract Creation of a nuclear export signal (NES) motif and loss of tryptophans (W) 288 and 290 (or 290 only) at the COOH terminus of nucleophosmin (NPM) are both crucial for NPM aberrant cytoplasmic accumulation in acute myelogenous leukemia (AML) carrying NPM1 mutations.
BOLLI, NICCOLO', NICOLETTI, Ildo, De Marco M. F., Bigerna B., PUCCIARINI, Alessandra, MANNUCCI, Roberta, MARTELLI, Maria Paola, LISO, Arcangelo, MECUCCI, Cristina, Fabbiano F., MARTELLI, Massimo Fabrizio, Henderson B., FALINI, Brunangelo   +12 more
openaire   +4 more sources