Results 121 to 130 of about 6,134,651 (270)

The Association between Assisted Reproductive Technologies and Neurodevelopmental Disorders in Offspring: An Overview of Current Evidence

Journal of Integrative Neuroscience
The utilization of assisted reproductive technologies (ART) is on the rise, resulting in a growing population of ART-conceived offspring. The health concerns of this unique population have attracted significant attention.
Zhitao Zeng, Zhuoyi Wang, Pengfei Yu, Yuchen Wang, Yuqiang Pei, Yujuan Dai, Yanping Liu, Ye Yang   +7 more
doaj   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring

Experimental Biology and Medicine
The antiretroviral (ARV) drug combination of abacavir sulfate, dolutegravir, and lamivudine [ABC/DTG/3TC; Tri combination Anti-retroviral therapy (TC-ART)] has revolutionized HIV treatment by effectively targeting different stages of viral replication ...
Yaswanthi Yanamadala, Chandra Mohan Reddy Muthumula, Kuppan Gokulan, Kumari Karn, Vicki Sutherland, Helen Cunny, Janine H. Santos, Sangeeta Khare   +7 more
doaj   +1 more source

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance

Advanced Science, EarlyView.
COL24A1 emerges as a collagen‐associated regulator of maternal‐fetal interface homeostasis. Its deficiency promotes a maladaptive TIMP1‐high stromal state, impaired ECM turnover, collagen accumulation, and stromal–immune dysregulation, contributing to pregnancy loss.
Teng Wu, Lingling Xie, Wenyi Liu, Hanjie Mo, Chengshu Xie, Jing Tang, Zhaorui Wang, Peixuan Lan, Jianping Zhang, Jie Gao, Qionglan Tang, Chunwei Cao, Hui Chen   +12 more
wiley   +1 more source

New Zealand regions, 1986-2001: Population structures [PDF]

, 2005
The age structure of a region’s population affects many areas of social and economic development across all sectors, including employment, housing, welfare, health and education.
Lindop, J., Pool, Ian, Baxendine, Sandra, Cochrane, William   +3 more
core  

Enhancing Specific Stiffness of Nano‐Architected Materials Through Generative AI and Active Learning

Advanced Science, EarlyView.
A structure‐centric generative framework searches voxelated design space directly, coupling a variational autoencoder with multi‐objective optimization and active learning to progressively expand the validated design domain. The discovered nano‐architectures, realized as pyrolytic carbon by two‐photon lithography, deliver 18–23% higher stiffness and 26–
Jinwook Yeo, Peter Serles, Donggeun Park, Julia R. Greer, Seunghwa Ryu   +4 more
wiley   +1 more source

Associations between OGTT results during pregnancy and offspring TSH levels: a birth cohort study

BMC Pregnancy and Childbirth
Background Limited evidence exists regarding the association between gestational diabetes mellitus (GDM) and elevated levels of thyroid-stimulating hormone (TSH) in newborns.
Meng Yang, Zhongqiang Cao, Wanting Zhu, Xiaoyuan Feng, Jieqiong Zhou, Jiuying Liu, Yuanyuan Zhong, Yan Zhou, Hong Mei, Xiaonan Cai, Liqin Hu, Aifen Zhou, Han Xiao   +12 more
doaj   +1 more source

Offspring-driven local dispersal in female sand lizards (Lacerta agilis)

, 2004
We report on a field study in which determinants of female breeding dispersal (i.e. the shift in the mean home range coordinates between successive breeding events) was investigated.
Anderholm, S (15497471), Ryberg, K (15497468), Madsen, T (15487754), Olsson, M (15487751), Ujvari, B (15497462), Erik Wapstra (14752204)   +5 more
core  

Offspring

, 2015
Data on sampled offspring (inlcuding assigments back to parents) caught at various life stages by electrofishing, in traps, or in the ...
McEvoy, Sarah, McGinnity, Philip, Cotter, Deirdre, Bailie, Deborah, Niall O'Maoileidigh (3322767), Dillane, Eileen, Paulo Prodöhl (3322770), Ger Rogan (3322788), Philip McGinnity (3250896), Sarah McEvoy (3322791), Ciar L O'Toole (3322776), Coughlan, Jamie, Tom Cross (3268050), O'Maoileidigh, Niall, O'Toole, Ciar L, Cross, Tom, Jamie Coughlan (3322779), Deborah Bailie (3322785), Rogan, Ger, Caroline Bradley (3322782), Eileen Dillane (410882), Prodöhl, Paulo, Reed, Thomas E., Bradley, Caroline, Thomas E. Reed (215744), Deirdre Cotter (3322773)   +25 more
core   +1 more source